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Anti-CXCR4 Antibody (3O921)
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产品编号 TMAH-00323
别名 WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184
Anti-CXCR4 Antibody (3O921) 是一种抗体，靶向 CXCR4。Anti-CXCR4 Antibody (3O921) 可用于 ELISA。
Anti-CXCR4 Antibody (3O921)
Anti-CXCR4 Antibody (3O921)
还可以产品编号 TMAH-00323 别名 WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184
Anti-CXCR4 Antibody (3O921) 是一种抗体，靶向 CXCR4。Anti-CXCR4 Antibody (3O921) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CXCR4 Antibody (3O921) is an antibody targeting CXCR4. Anti-CXCR4 Antibody (3O921) can be used in ELISA. |
| 别名 | WHIMS, WHIM, NPYY3R, NPYRL, NPYR, NPY3R, LESTR, LCR1, LAP-3, LAP3, HSY3RR, HM89, FB22, D2S201E, chemokine (C-X-C motif) receptor 4, CD184 |
| Ig Type | Human IgG4(S228P) |
| 克隆号 | 3O921 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of Human CXCR4 with Anti-CXCR4 recombinant Antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CXCR4 at 10 μg/mL can bind Anti-CXCR4 recombinant antibody, the EC50 is 101.7-253.6 ng/mL. |
| 应用 | |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC). |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CXCR4 Protein |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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