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Anti-CXCL16 Antibody (6K332)
还可以产品编号 TMAY-03758
别名 SR-PSOX, SRPSOX, CXCLG16, chemokine (C-X-C motif) ligand 16
Anti-CXCL16 Antibody (6K332) 是一种 Mouse 抗体，靶向 CXCL16。Anti-CXCL16 Antibody (6K332) 可用于 ELISA。
Anti-CXCL16 Antibody (6K332)
Anti-CXCL16 Antibody (6K332)
还可以产品编号 TMAY-03758 别名 SR-PSOX, SRPSOX, CXCLG16, chemokine (C-X-C motif) ligand 16
Anti-CXCL16 Antibody (6K332) 是一种 Mouse 抗体，靶向 CXCL16。Anti-CXCL16 Antibody (6K332) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CXCL16 Antibody (6K332) is a Mouse antibody targeting CXCL16. Anti-CXCL16 Antibody (6K332) can be used in ELISA. |
| 别名 | SR-PSOX, SRPSOX, CXCLG16, chemokine (C-X-C motif) ligand 16 |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6K332 |
| 交叉反应 | Rat |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat CXCL16 / SR-PSOX (TMPY-02754; Q6AXU5; Met1-Ala198). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS with 10% Trehalose, 0.02% Tween 80, pH7.0 |
| 研究背景 | C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL16 exists in transmembrane and soluble forms. The transmembrane form acts as a scavenger receptor for oxidised LDL whereas the soluble form acts a chemoattractant for mainly CD8+ T cells. CXCL16 is a protein which shares pattern recognition receptor functions, relevant for adhesion and phagocytosis of bacterial products, with the properties of an adhesion molecule and inflammatory chemokine. CXCL16/SR-PSOX is an interferon-gamma-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. Proteolytic cleavage of membrane-bound CXCL16 releases soluble CXCL16, which may promote migration of effector T cells and augment a proatherogenic inflammatory response. CXCL16/SR-PSOX can be a potential player in atherogenesis. Enhanced expression of CXCL16 has been demonstrated in atherosclerotic plaques and several properties have been attributed to CXCL16 that could influence the atherosclerotic process. Following in vitro studies suggested that as an adhesion molecule CXCL16/SR-PSOX might mediate T-cell adhesion to the endothelium, as a chemokine-drive T-cell migration, stimulate cell proliferation and elicit inflammatory phenotype in smooth muscle cells (SMC) and, finally, as a scavenger receptor-mediate uptake of atherogenic lipoproteins by macrophages and SMC. CXCR6 and its ligand CXCL16 in regulating metastasis and invasion of cancer. CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. In addition, both CXCR6 and CXCL16 levels increase as tumor malignancy increases. Thus, CXCL16 and CXCR6 may mark cancers arising in an inflammatory milieu and mediate pro-tumorigenic effects of inflammation through direct effects on cancer cell growth and by inducing the migration and proliferation of tumor-associated leukocytes. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Rat CXCL16 / SR-PSOX protein (TMPY-02754) |
| 抗原种属 | Rat |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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