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Anti-Cullin 2 Antibody (5U128)
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产品编号 TMAC-01019
别名 MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2
Anti-Cullin 2 Antibody (5U128) 是一种 Rabbit 抗体，靶向 Cullin 2。Anti-Cullin 2 Antibody (5U128) 可用于 WB,IHC,IP。
Anti-Cullin 2 Antibody (5U128)
Anti-Cullin 2 Antibody (5U128)
还可以产品编号 TMAC-01019 别名 MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2
Anti-Cullin 2 Antibody (5U128) 是一种 Rabbit 抗体，靶向 Cullin 2。Anti-Cullin 2 Antibody (5U128) 可用于 WB,IHC,IP。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,480 | 5日内发货 | |
| 100 μL | ¥ 2,495 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-Cullin 2 Antibody (5U128) is a Rabbit antibody targeting Cullin 2. Anti-Cullin 2 Antibody (5U128) can be used in WB,IHC,IP. |
| 别名 | MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2 |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of Cullin 2 on PC-3M and K562 cell lysates using anti-Cullin 2 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-Cullin 2 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cullin 2 antibody. Counter stained with hematoxylin. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC: 1:50-200; IP: 1:10-50 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex. |
| 偶联 | Unconjugated |
| Uniprot ID |
| 分子量 | Theoretical: 89 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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