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Anti-Cullin 2 Antibody (5U128)

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产品编号 TMAC-01019

别名 MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2

Anti-Cullin 2 Antibody (5U128) 是一种 Rabbit 抗体，靶向 Cullin 2。Anti-Cullin 2 Antibody (5U128) 可用于 IHC,IP,WB。

Anti-Cullin 2 Antibody (5U128)

Anti-Cullin 2 Antibody (5U128)

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Rating icon 还可以
产品编号 TMAC-01019 别名 MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2

Anti-Cullin 2 Antibody (5U128) 是一种 Rabbit 抗体，靶向 Cullin 2。Anti-Cullin 2 Antibody (5U128) 可用于 IHC,IP,WB。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

生物活性
产品描述
Anti-Cullin 2 Antibody (5U128) is a Rabbit antibody targeting Cullin 2. Anti-Cullin 2 Antibody (5U128) can be used in IHC,IP,WB.
别名MGC131970, Cullin-2, cullin2, cullin homolog 2, CUL2_HUMAN, CUL-2, Cul2, CUL2, CUL 2
Ig Type
IgG
克隆号
5U128
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Cullin 2 on PC-3M and K562 cell lysates using anti-Cullin 2 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded rat testis tissue using anti-Cullin 2 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Cullin 2 antibody. Counter stained with hematoxylin.
verifiedActivityverifiedActivityverifiedActivity
应用IHCIPWB
推荐剂量
WB: 1:500-2000; IHC: 1:50-200; IP: 1:10-50
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Cullin proteins comprise a distinct family of mediators that participate in the selective targeting of proteins for ubiquitin (Ub)-mediated proteolysis. CUL-1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL-1/F-box protein complex) consists of Skp1 associating with both CUL-1 and an F-box protein, such as Skp2, which determines the substrate specificity of the complex. CUL-1-mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL-3, facilitates the degradation of cyclin E independent of SCF activity, while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase. Proteolysis also occurs by way of CUL-4 associating with Nedd-8, a ubiquitin-like protein, where it too functions as an active component of a multifunctional E3 complex.
偶联与修饰
偶联
Unconjugated
抗原信息
Uniprot ID
Q13617
化学信息
分子量Theoretical: 89 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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