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Anti-CUEDC2 Antibody (8G619)
还可以产品编号 TMAY-01869
Anti-CUEDC2 Antibody (8G619) 是一种 Rabbit 抗体，靶向 CUEDC2。Anti-CUEDC2 Antibody (8G619) 可用于 ELISA,IHC-P。
Anti-CUEDC2 Antibody (8G619)
Anti-CUEDC2 Antibody (8G619)
还可以产品编号 TMAY-01869
Anti-CUEDC2 Antibody (8G619) 是一种 Rabbit 抗体，靶向 CUEDC2。Anti-CUEDC2 Antibody (8G619) 可用于 ELISA,IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CUEDC2 Antibody (8G619) is a Rabbit antibody targeting CUEDC2. Anti-CUEDC2 Antibody (8G619) can be used in ELISA,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 8G619 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human CUEDC2 in human breast carcinoma with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| 应用 | ELISA,IHC-P |
| 推荐剂量 | ELISA: 1:5000-1:10000; IHC-P: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human CUEDC2. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | CUE domain-containing 2 (CUEDC2) is a protein involved in the regulation of the cell cycle, inflammation, and tumorigenesis and is highly expressed in many types of tumors. CUEDC2 is phosphorylated by Cdk1 during mitosis and promotes the release of anaphase-promoting complex or cyclosome (APC/C) from checkpoint inhibition. CUEDC2 is also known to interact with IkB kinase alpha (IKKalpha) and IKKbeta and has an inhibitory role in the activation of transcription factor nuclear factor-kappaB. Moreover, CUEDC2 plays an important role in downregulating the expression of hormone receptors estrogen receptor-alpha and progesterone receptor, thereby impairing the responsiveness of breast cancer to endocrine therapies. The expression level of CUEDC2 has an inverse correlation with imatinib resistance and activity of NF-kappaB signaling pathway in CML cells, CUEDC2 could regulate imatinib sensitivity in CML cells at least partially through NF-kappaB signaling pathway. CUEDC2 may be a promising biomarker to evaluate the progression of serous ovarian carcinoma and to predict likely relapse of ovarian serous carcinoma. The decreased expression of CUEDC2 contributes to tumor growth in lung adenocarcinoma, leading to a poor clinical outcome. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CUEDC2 protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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