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Anti-Coagulation factor XI/F11 Antibody (9T435)
还可以产品编号 TMAY-00585
Anti-Coagulation factor XI/F11 Antibody (9T435) 是一种 Rabbit 抗体，靶向 Coagulation factor XI/F11。Anti-Coagulation factor XI/F11 Antibody (9T435) 可用于 ELISA。
Anti-Coagulation factor XI/F11 Antibody (9T435)
Anti-Coagulation factor XI/F11 Antibody (9T435)
还可以产品编号 TMAY-00585
Anti-Coagulation factor XI/F11 Antibody (9T435) 是一种 Rabbit 抗体，靶向 Coagulation factor XI/F11。Anti-Coagulation factor XI/F11 Antibody (9T435) 可用于 ELISA。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Coagulation factor XI/F11 Antibody (9T435) is a Rabbit antibody targeting Coagulation factor XI/F11. Anti-Coagulation factor XI/F11 Antibody (9T435) can be used in ELISA. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 9T435 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Coagulation Factor XI / F11 (rh Coagulation Factor XI / F11; TMPY-01104; NP_000119.1; Met1-Val625). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | HRP |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human Coagulation Factor XI / F11 protein (TMPY-01104) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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