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Anti-Coagulation factor X/F10 Antibody (6U812)
还可以产品编号 TMAY-01598
Anti-Coagulation factor X/F10 Antibody (6U812) 是一种 Mouse 抗体，靶向 Coagulation factor X/F10。Anti-Coagulation factor X/F10 Antibody (6U812) 可用于 ELISA(Cap)。
Anti-Coagulation factor X/F10 Antibody (6U812)
Anti-Coagulation factor X/F10 Antibody (6U812)
还可以产品编号 TMAY-01598
Anti-Coagulation factor X/F10 Antibody (6U812) 是一种 Mouse 抗体，靶向 Coagulation factor X/F10。Anti-Coagulation factor X/F10 Antibody (6U812) 可用于 ELISA(Cap)。
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| 产品描述 | Anti-Coagulation factor X/F10 Antibody (6U812) is a Mouse antibody targeting Coagulation factor X/F10. Anti-Coagulation factor X/F10 Antibody (6U812) can be used in ELISA(Cap). |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 6U812 |
| 交叉反应 | Human |
| 应用 | ELISA(Cap) |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Coagulation Factor X/F10 (rh Coagulation Factor X/F10; TMPY-01101; NP_000495.1; Met1-Lys488). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hemarthroses, hematomas, and umbilical cord, gastrointestinal, and central nervous system bleeding. Factor X is synthesized in the liver as a mature heterodimer formed from a single-chain precursor, and vitamin K is essential for its synthesis. Factor X is activated into factor Xa (FXa) by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII (with its cofactor, tissue factor in a complex known as extrinsic Xase) through cleaving the activation propeptide. As the first member of the final common pathway or thrombin pathway, FXa converts prothrombin to thrombin in the presence of factor Va, Ca2+, and phospholipid during blood clotting and cleaves prothrombin in two places (an arg-thr and then an arg-ile bond). This process is optimized when factor Xa is complexed with activated cofactor V in the prothrombinase complex. Inborn deficiency of factor X is very uncommon, and may present with epistaxis (nose bleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. Furthermore, factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the vasculature. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Coagulation Factor X/F10 Protein (TMPY-01101) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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