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Anti-Claudin-18 Antibody (2Q277)
还可以产品编号 TMAY-01429
Anti-Claudin-18 Antibody (2Q277) 是一种 Mouse 抗体，靶向 Claudin-18。Anti-Claudin-18 Antibody (2Q277) 可用于 IHC-P。
Anti-Claudin-18 Antibody (2Q277)
Anti-Claudin-18 Antibody (2Q277)
还可以产品编号 TMAY-01429
Anti-Claudin-18 Antibody (2Q277) 是一种 Mouse 抗体，靶向 Claudin-18。Anti-Claudin-18 Antibody (2Q277) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Claudin-18 Antibody (2Q277) is a Mouse antibody targeting Claudin-18. Anti-Claudin-18 Antibody (2Q277) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG2a |
| 克隆号 | 2Q277 |
| 交叉反应 | Human, Has cross-reactivity in IHC with human Claudin 18.1 and Claudin 18.2 |
| 验证活性 | 1. Immunochemical staining of human Claudin 18 in human stomach with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human Claudin 18 in human gastric cancer with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human Claudin 18 in human lung with mouse monoclonal antibody at 1:2000 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:1000-1:5000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the C-terminus of the human Claudin 18. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the C-terminus human Claudin 18 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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