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顶部生物活性储存和溶解信息计算器

Anti-CDK4 Antibody (8K220)

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产品编号 TMAH-00254

别名 PSK-J3, cyclin-dependent kinase 4, CMM3

Anti-CDK4 Antibody (8K220) 是一种抗体，靶向 CDK4。Anti-CDK4 Antibody (8K220) 可用于 ELISA,WB。

Anti-CDK4 Antibody (8K220)

Anti-CDK4 Antibody (8K220)

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产品编号 TMAH-00254 别名 PSK-J3, cyclin-dependent kinase 4, CMM3

Anti-CDK4 Antibody (8K220) 是一种抗体，靶向 CDK4。Anti-CDK4 Antibody (8K220) 可用于 ELISA,WB。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-CDK4 Antibody (8K220) is an antibody targeting CDK4. Anti-CDK4 Antibody (8K220) can be used in ELISA,WB.
别名PSK-J3, cyclin-dependent kinase 4, CMM3
Ig Type
Rabbit IgG
克隆号
8K220
交叉反应
Human
验证活性
Western Blot
-Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate
-All lanes: CDK4 antibody at 1:1500
-Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution
-Predicted band size: 34, 21 kDa
-Observed band size: 34 kDa
应用ELISAWB
推荐剂量
WB:1:500-1:5000.
抗体种类
Monoclonal
亚细胞定位Cytoplasm. Nucleus. Nucleus membrane.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human CDK4
抗原种属
Human
基因名称
CDK4
基因ID
1019
Uniprot ID
P11802
研究领域
Isotype/Loading Controls, Epigenetics and Nuclear Signaling, Cancer, Cell biology
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

CMM-3CMM 3

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