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顶部生物活性储存和溶解信息计算器

Anti-CDK4 Antibody (5A439)

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Anti-CDK4 Antibody (5A439)
产品编号 TMAC-00793
别名 PSK-J3, cyclin-dependent kinase 4, CMM3

Anti-CDK4 Antibody (5A439) 是一种 Rabbit 抗体，靶向 CDK4。Anti-CDK4 Antibody (5A439) 可用于 WB,ICC/IF,IP。

Anti-CDK4 Antibody (5A439)

Anti-CDK4 Antibody (5A439)

Rating icon 还可以
Anti-CDK4 Antibody (5A439)
产品编号 TMAC-00793 别名 PSK-J3, cyclin-dependent kinase 4, CMM3

Anti-CDK4 Antibody (5A439) 是一种 Rabbit 抗体，靶向 CDK4。Anti-CDK4 Antibody (5A439) 可用于 WB,ICC/IF,IP。

规格价格库存数量
50 μL
¥ 1,490
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-CDK4 Antibody (5A439) is a Rabbit antibody targeting CDK4. Anti-CDK4 Antibody (5A439) can be used in WB,ICC/IF,IP.
别名PSK-J3, cyclin-dependent kinase 4, CMM3
Ig Type
IgG
交叉反应
Human,Mouse,Rat
验证活性
1. Western blot analysis of Cdk4 on different lysates using anti-Cdk4 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7, Lane 3: K562.
2. ICC staining Cdk4 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining Cdk4 in AGS cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining Cdk4 in NIH/3T3 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC/IF
IP
推荐剂量
WB: 1:1000-2000; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Cell cycle progression is controlled in part by a family of cyclin proteins and cyclin dependent kinases (Cdks). Cdk proteins work in concert with the cyclins to phosphorylate key substrates involved in each phase of cell cycle progression. Another family of proteins, Cdk inhibitors, also plays a role in regulating the cell cycle by binding to cyclin-Cdk complexes and modulating their activity. Several Cdk proteins have been identified, including Cdk2-Cdk8, PCTAIRE-1-PCTAIRE-3, PITALRE and PITSLRE. Cdk4, in complex with D-type cyclins, is thought to regulate cell growth during the G1 phase of the cell cycle. This association with a D-type cyclin upregulates Cdk4 activity, whereas binding to the Cdk inhibitor p16 downregulates Cdk4 activity. Activation of the Cdk4-cyclin complexes requires phosphorylation on a single threonyl residue of Cdk4, catalyzed by a Cdk-activating protein (CAK).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
P11802
化学信息
分子量Theoretical: 34 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

CMM-3CMM 3

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