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Anti-CD98 Antibody (5V304)
还可以产品编号 TMAY-02278
Anti-CD98 Antibody (5V304) 是一种 Mouse 抗体，靶向 CD98。Anti-CD98 Antibody (5V304) 可用于 ICC/IF。
Anti-CD98 Antibody (5V304)
Anti-CD98 Antibody (5V304)
还可以产品编号 TMAY-02278
Anti-CD98 Antibody (5V304) 是一种 Mouse 抗体，靶向 CD98。Anti-CD98 Antibody (5V304) 可用于 ICC/IF。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD98 Antibody (5V304) is a Mouse antibody targeting CD98. Anti-CD98 Antibody (5V304) can be used in ICC/IF. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5V304 |
| 交叉反应 | Human |
| 验证活性 | ImmunoFluorscence staining of SLC3A2 in MCF7 cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with mouse anti-Human SLC3A2 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®594-conjugated Goat Anti-mouse IgG secondary antibody (red) and counterstained with DAPI (blue).Positive staining was localized to Cytoplasm and Cell membrane. |
| 应用 | ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD98/SLC3A2 (rh CD98/SLC3A2; TMPY-01938; P08195-1; Arg206-Ala630). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | 4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD98/SLC3A2 Protein (TMPY-01938) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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