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Anti-CD8 alpha Antibody (3P65)
还可以产品编号 TMAY-01408
Anti-CD8 alpha Antibody (3P65) 是一种 Mouse 抗体，靶向 CD8 alpha。Anti-CD8 alpha Antibody (3P65) 可用于 IHC-P。
Anti-CD8 alpha Antibody (3P65)
Anti-CD8 alpha Antibody (3P65)
还可以产品编号 TMAY-01408
Anti-CD8 alpha Antibody (3P65) 是一种 Mouse 抗体，靶向 CD8 alpha。Anti-CD8 alpha Antibody (3P65) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-CD8 alpha Antibody (3P65) is a Mouse antibody targeting CD8 alpha. Anti-CD8 alpha Antibody (3P65) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3P65 |
| 交叉反应 | Human, Mouse |
| 验证活性 | 1. Immunochemical staining CD8A in human tonsil with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining CD8A in human lymph node with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining CD8A in mouse spleen with mouse monoclonal antibody at 1:200 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD8/CD8 alpha/Leu-2 (rh CD8/CD8 alpha/Leu-2; NP_001759.3Met1-Asp182). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | T-cell surface glycoprotein CD8 alpha chain, also known as CD8a, is a single-pass type I membrane protein. The CD8 glycoprotein is expressed by thymocytes, mature T cells and natural killer (NK) cells and has been implicated in the recognition of monomorphic determinants on major histocompatibility complex (MHC) Class I antigens, and in signal transduction during the course of T-cell activation. Both human and rodent CD8 antigens are comprised of two distinct polypeptide chains, alpha and beta. The Ig domains of CD8 alpha are involved in controlling the ability of CD8 to be expressed. Mutation of B- and F-strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and, therefore, to be expressed. Defects in CD8A are a cause of familial CD8 deficiency. Familial CD8 deficiency is a novel autosomal recessive immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human CD8/CD8 alpha/Leu-2 Protein |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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