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Anti-CD74 Antibody (9A838)
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产品编号 TMAH-00220
别名 II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain
Anti-CD74 Antibody (9A838) 是一种抗体，靶向 CD74。Anti-CD74 Antibody (9A838) 可用于 ELISA。
Anti-CD74 Antibody (9A838)
Anti-CD74 Antibody (9A838)
还可以产品编号 TMAH-00220 别名 II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain
Anti-CD74 Antibody (9A838) 是一种抗体，靶向 CD74。Anti-CD74 Antibody (9A838) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-CD74 Antibody (9A838) is an antibody targeting CD74. Anti-CD74 Antibody (9A838) can be used in ELISA. |
| 别名 | II, Ia-γ, Ia-GAMMA, HLADG, DHLAG, CD74 molecule, major histocompatibility complex, class II invariant chain |
| Ig Type | Human IgG1 |
| 克隆号 | 9A838 |
| 交叉反应 | Human |
| 验证活性 | The Binding Activity of Human CD74 with Anti-CD74 recombinant antibody Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CD74 at 2 μg/mL can bind Anti-CD74 recombinant antibody, the EC50 is 1.317-1.646 ng/mL. |
| 应用 | ELISA |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; [Isoform p41]: Late endosome. Lysosome. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. |
| 研究背景 | Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human CD74 Protein |
| 抗原种属 | Human |
| 基因ID | 972 |
| Uniprot ID | |
| 研究领域 | Immunology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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