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Anti-CD16a Antibody (5Q84) 是一种 Rabbit 抗体,靶向 CD16a。Anti-CD16a Antibody (5Q84) 可用于 ELISA。
Anti-CD16a Antibody (5Q84) 是一种 Rabbit 抗体,靶向 CD16a。Anti-CD16a Antibody (5Q84) 可用于 ELISA。
产品描述 | Anti-CD16a Antibody (5Q84) is a Rabbit antibody targeting CD16a. Anti-CD16a Antibody (5Q84) can be used in ELISA. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 5Q84 |
交叉反应 | Rat |
应用 | ELISA |
推荐剂量 | ELISA: 1:5000-1:10000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD16a / FCGR3A (TMPY-02018; ABO70343.1; Met1-Pro200). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells. CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation. |
偶联 | Unconjugated |
免疫原 | Recombinant Rat CD16a / FCGR3A protein (TMPY-02018) |
抗原种属 | Rat |
研究领域 | Fc Receptors, Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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