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Anti-Cathepsin L Antibody (7U669)
还可以产品编号 TMAY-00892
Anti-Cathepsin L Antibody (7U669) 是一种 Rabbit 抗体，靶向 Cathepsin L。Anti-Cathepsin L Antibody (7U669) 可用于 WB。
Anti-Cathepsin L Antibody (7U669)
Anti-Cathepsin L Antibody (7U669)
还可以产品编号 TMAY-00892
Anti-Cathepsin L Antibody (7U669) 是一种 Rabbit 抗体，靶向 Cathepsin L。Anti-Cathepsin L Antibody (7U669) 可用于 WB。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Cathepsin L Antibody (7U669) is a Rabbit antibody targeting Cathepsin L. Anti-Cathepsin L Antibody (7U669) can be used in WB. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 7U669 |
| 交叉反应 | Human |
| 验证活性 | 1. Anti-CTSL1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: A549 Whole Cell Lysate. -Lane C: HCT116 Whole Cell Lysate. -Lane D: U87MG Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:36 kDa. -Observed band size:25 kDa. 2. Anti-CTSL1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: A549 Whole Cell Lysate. -Lane B: CTSL1 konckout A549 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:36 kDa. -Observed band size:25 kDa |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin L / CTSL / CTSL1 (rh Cathepsin L / CTSL / CTSL1; TMPY-00734; NP_001903.1; Met1-Val333). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cathepsin L is a lysosomal cysteine protease that plays a major role in intracellular protein catabolism, and is potent in degrading collagen, laminin, elastin, as well as alpha-1 protease inhibitor and other structural proteins of basement membranes. It is secreted by liver flukes at all stages of their development in the mammalian host, are believed to play important roles in facilitating parasite migration (tissue degradation), feeding and immuno-evasion. Like many proteases, Cathepsin L is synthesized as an inactive preproenzyme, and cleavage of the 96-residue proregion is necessary to generate the fully active 221-residue mature enzyme. Studies have demonstrated that cleavage of the proregion occur autocatalytically under acidic conditions. The enzyme takes part in nutrient acquisition by catabolizing host proteins to absorbable peptides, facilitates the migration of the parasite through the host intestine and liver by cleaving interstitial matrix proteins such as fibronectin, laminin and native collagen and is implicated in the inactivation of host immune defenses by cleaving immunoglobulins. Recently, Cathepsin L has been shown to suppress Th1 immune response in infected laboratory animals making them susceptible to concurrent bacterial infections. Cathepsin L is synthesized in large amounts and secreted by many malignantly transformed cells, and induced by growth factors and tumor promoters. In addition to its role in protein degradation, evidence has accumulated for the participation of Cathepsin L in various physiological and pathological processes, such as tumor invasion and metastasis, bone resorption, spermatogenesis, and arthritis. Accordingly, Cathepsin L may prove useful as a diagnostic or prognostic marker of human tumor malignancy. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Cathepsin L / CTSL / CTSL1 protein (TMPY-00734) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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