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顶部生物活性储存和溶解信息计算器

Anti-Cathepsin D Antibody (5Z751)

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Anti-Cathepsin D Antibody (5Z751)
产品编号 TMAY-03121
别名 HEL-S-130P, CPSD, CLN10, cathepsin D

Anti-Cathepsin D Antibody (5Z751) 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Antibody (5Z751) 可用于 WB,ELISA,IP。

Anti-Cathepsin D Antibody (5Z751)
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Anti-Cathepsin D Antibody (5Z751)

Rating icon 还可以
Anti-Cathepsin D Antibody (5Z751)
产品编号 TMAY-03121 别名 HEL-S-130P, CPSD, CLN10, cathepsin D

Anti-Cathepsin D Antibody (5Z751) 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Antibody (5Z751) 可用于 WB,ELISA,IP。

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100 μL
¥ 2,289
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产品介绍

生物活性
产品描述
Anti-Cathepsin D Antibody (5Z751) is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Antibody (5Z751) can be used in WB,ELISA,IP.
别名HEL-S-130P, CPSD, CLN10, cathepsin D
Ig Type
Rabbit IgG
克隆号
5Z751
交叉反应
Mouse
验证活性
1. Mouse CTSD was immunoprecipitated using:
-Lane A:0.5 mg MCF-7 Whole Cell Lysate.
-Lane B:0.5 mg HepG2 Whole Cell Lysate
-0.5 µL anti-Mouse CTSD rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose.
-Primary antibody:
-Anti-Mouse CTSD rabbit monoclonal antibody, at 1:500 dilution.
-Secondary antibody:
-Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution.
-Developed using the odyssey technique.
-Performed under reducing conditions.
-Predicted band size: 45 kDa.
-Observed band size: 45 kDa.
2. Anti-CTSD rabbit monoclonal antibody at 1:500 dilution.
-Lane A: MCF7 Whole Cell lysate.
-Lysates/proteins at 30 μg per lane.
-Secondary
-Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.
-Developed using the Odyssey technique.
-Performed under reducing conditions.
-Predicted band size:45 kDa.
-Observed band size:45 kDa(We are unsure as to the identity of these extra bands.)
应用
WB,ELISA,IP
推荐剂量
WB: 1:500-1:1000; ELISA: 1:25000-1:50000; IP: 1-2 μL/mg of lysate
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Cathepsin D / CTSD (rM Cathepsin D / CTSD; TMPY-00733; NP_034113.1; Met 1-Leu 410).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Mouse Cathepsin D / CTSD Protein (TMPY-00733)
抗原种属
Mouse
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

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关键词

CLN-10CLN 10

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