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Anti-Cathepsin D Antibody (2Y136)
还可以产品编号 TMAY-02375
Anti-Cathepsin D Antibody (2Y136) 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Antibody (2Y136) 可用于 WB,IHC-P。
Anti-Cathepsin D Antibody (2Y136)
Anti-Cathepsin D Antibody (2Y136)
还可以产品编号 TMAY-02375
Anti-Cathepsin D Antibody (2Y136) 是一种 Rabbit 抗体，靶向 Cathepsin D。Anti-Cathepsin D Antibody (2Y136) 可用于 WB,IHC-P。
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偶联与修饰
抗原信息
| 产品描述 | Anti-Cathepsin D Antibody (2Y136) is a Rabbit antibody targeting Cathepsin D. Anti-Cathepsin D Antibody (2Y136) can be used in WB,IHC-P. |
| Ig Type | Monoclonal Rabbit IgG |
| 克隆号 | 2Y136 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human CTSD in human lung cancer with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human CTSD in human cirrhosis with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 3. Anti-CTSD rabbit monoclonal antibody at 1:500 dilution. -Lane A: MCF7 Whole Cell Lysate. -Lane B: A431 Whole Cell Lysate. -Lane C: HepG2 Whole Cell Lysate. -Lane D: SKBR3 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:45 kDa. -Observed band size:31 kDa. 4. Anti-CTSD rabbit monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: CTSD konckout 293T Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:45 kDa. -Observed band size:31 kDa |
| 应用 | WB,IHC-P |
| 推荐剂量 | WB: 1:500-1:2000; IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Human Cathepsin D / CTSD (rh Cathepsin D / CTSD; TMPY-02450; P07339; Met1-Leu412). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cathepsin D (CTSD), a well known lysosomal aspartyl protease and belongs to the peptidase C1 family, which is a normal and major component of lysosomes, and is found in almost all cells and tissues of mammals. Its mostly described function is intracellular catabolism in lysosomal compartments, other physiological effect include hormone and antigen processing. Cathepsin D has a specificity similar to but narrower than that of pepsin A. Cathepsin D plays an important role in the degradation of proteins, the generation of bioactive proteins, antigen processing, etc. Among different role in cell physiology, a new function of this enzyme is examined. Cathepsin D is an important regulator of apoptotic pathways in cells. It acts at different stage of intrinsic and extrinsic pathway of apoptosis. In addition, CTSD secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis, suggesting its contribution to the prevention of tumor growth and angiogenesis-dependent growth of metastases. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Cathepsin D / CTSD protein (TMPY-02450) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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