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Anti-Carbonic Anhydrase 9 Antibody (7K666) 是一种 Rabbit 抗体,靶向 Carbonic Anhydrase 9。Anti-Carbonic Anhydrase 9 Antibody (7K666) 可用于 IHC-P。
Anti-Carbonic Anhydrase 9 Antibody (7K666) 是一种 Rabbit 抗体,靶向 Carbonic Anhydrase 9。Anti-Carbonic Anhydrase 9 Antibody (7K666) 可用于 IHC-P。
产品描述 | Anti-Carbonic Anhydrase 9 Antibody (7K666) is a Rabbit antibody targeting Carbonic Anhydrase 9. Anti-Carbonic Anhydrase 9 Antibody (7K666) can be used in IHC-P. |
Ig Type | Monoclonal Rabbit IgG |
克隆号 | 7K666 |
交叉反应 | Mouse |
验证活性 | Immunochemical staining of mouse CAR9 in mouse stomach (from 2 donors) with rabbit monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
应用 | IHC-P |
推荐剂量 | IHC-P: 1:250-1:1000 |
抗体种类 | Monoclonal |
宿主来源 | Rabbit |
构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Carbonic Anhydrase IX / CAR9 (rM Carbonic Anhydrase IX / CAR9; TMPY-01700; NP_647466.2; Met1-Asp390). |
纯化方式 | Protein A |
性状 | Liquid |
缓冲液 | 0.2 μm filtered solution in PBS |
研究背景 | Carbonic anhydrases IX (CA IX), also known as membrane antigen MN or CA9, is a member of the carbonic anhydrase (CA) family and may be involved in cell proliferation and cellular transformation. CAs are zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide (H2O + CO2 = H+ + HCO3–) and thus participate in a variety of biological and physical processes. CA IX protein is expressed primarily in carcinoma cells lines, and the expression is cell density dependent and has been shown to be strongly induced by hypoxia, accordingly facilitates adaptation of tumor cells to hypoxic conditions. It is involved in tumorigenesis through many pathways, such as pH regulation and cell adhesion control. CA IX is used as a marker of tumor hypoxia and as a new therapeutic target for many human carcinomas and cancers.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
偶联 | Unconjugated |
免疫原 | Recombinant Mouse Carbonic Anhydrase IX / CAR9 protein (TMPY-01700) |
抗原种属 | Mouse |
研究领域 | Cancer Drug Targets |
储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
运输方式 | Shipping with blue ice. |
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