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Anti-BUB1 Antibody (7B946)
还可以产品编号 TMAH-00124
别名 Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1
Anti-BUB1 Antibody (7B946) 是一种抗体，靶向 BUB1。Anti-BUB1 Antibody (7B946) 可用于 ELISA, WB。
Anti-BUB1 Antibody (7B946)
Anti-BUB1 Antibody (7B946)
还可以产品编号 TMAH-00124 别名 Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1
Anti-BUB1 Antibody (7B946) 是一种抗体，靶向 BUB1。Anti-BUB1 Antibody (7B946) 可用于 ELISA, WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,180 | 5日内发货 |
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产品介绍
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抗原信息
| 产品描述 | Anti-BUB1 Antibody (7B946) is an antibody targeting BUB1. Anti-BUB1 Antibody (7B946) can be used in ELISA, WB. |
| 别名 | Mitotic checkpoint serine/threonine-protein kinase BUB1, hBUB1, EC 2.7.11.1, BUB1L, BUB1A, BUB 1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 7B946 |
| 交叉反应 | Human |
| 验证活性 | Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, HepG2 whole cell lysate -All lanes: Bub1 antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 123, 116, 120 kDa -Observed band size: 130 kDa |
| 应用 | ELISA, WB |
| 推荐剂量 | WB:1:500-1:5000. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Nucleus. Chromosome, centromere, kinetochore. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human Bub1 |
| 抗原种属 | Human |
| 基因ID | 699 |
| Uniprot ID | |
| 研究领域 | Cancer, Cell biology |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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