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Anti-Bikunin/AMBP Antibody (9R49)
还可以产品编号 TMAY-02499
别名 α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M
Anti-Bikunin/AMBP Antibody (9R49) 是一种 Mouse 抗体，靶向 Bikunin/AMBP。Anti-Bikunin/AMBP Antibody (9R49) 可用于 IHC-P。
Anti-Bikunin/AMBP Antibody (9R49)
Anti-Bikunin/AMBP Antibody (9R49)
还可以产品编号 TMAY-02499 别名 α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M
Anti-Bikunin/AMBP Antibody (9R49) 是一种 Mouse 抗体，靶向 Bikunin/AMBP。Anti-Bikunin/AMBP Antibody (9R49) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,689 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Bikunin/AMBP Antibody (9R49) is a Mouse antibody targeting Bikunin/AMBP. Anti-Bikunin/AMBP Antibody (9R49) can be used in IHC-P. |
| 别名 | α-1-microglobulin/bikunin precursor, UTI, ITILC, ITIL, ITI, IATIL, HI30, HCP, EDC1, alpha-1-microglobulin/bikunin precursor, A1M |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 9R49 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human A1pha-1-microglobulin in human liver with mouse monoclonal antibody at 1:60 dilution, formalin-fixed paraffin embedded sections. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:30-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Protein HC/Bikunin (rh Protein HC/Bikunin; TMPY-03044; NP_001624.1; Met1-Val203). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | The AMBP [A1M (alpha1-microglobulin)/bikunin precursor] gene encodes two plasma glycoproteins: A1M, an immunosuppressive lipocalin, and bikunin, a member of plasma serine proteinase inhibitor family with prototypical Kunitz-type domain. Although previously believed to be constitutively expressed exclusively in liver, the present study demonstrates the induction of this gene by oxalate in porcine proximal tubular LLC-PK1 cells and rat kidney. In liver, the precursor protein is cleaved in the Golgi network by a furin-like enzyme to release constituent proteins, which undergo glycosylation before their export from the cell. In the renal tubular cells, A1M and bikunin co-precipitate, indicating lack of cleavage of the precursor protein. As the expression of the AMBP gene is regulated by A1M-specific cis elements and transcription factors, A1M protein was studied as a representative of AMBP gene expression in renal cells. The alpha(1)-microglobulin/bikunin precursor (AMBP) gene, and its two protein products were studied in mouse embryos of 8.5-15.5 days of embryonic development by in situ hybridization and immunohistochemistry. AMBP mRNA is strongly transcribed in liver parenchyma, pancreas, and intestine epithelium. Sites of weaker expression are the vessels of the umbilical cord, the developing vertebral bodies, and kidney. The alpha(1)-microglobulin and bikunin proteins are accordingly present in developing hepatocytes, pancreas, kidney, and gut. However, additional sites of protein distribution were found that do not correlate to mRNA localization: alpha(1)-microglobulin was found in myocytes and bikunin in cardiac muscle, nervous system microvasculature, and connective tissue |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Protein HC/Bikunin Protein (TMPY-03044) |
| 抗原种属 | Human |
| 研究领域 | Serine Proteases and Regulators |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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