Anti-ARSA Antibody (9A5)

Name: Anti-ARSA Antibody (9A5)
Brand: TargetMol
SKU: TMAY-00845
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00845

Anti-ARSA Antibody (9A5) 是一种 Rabbit 抗体，靶向 ARSA。Anti-ARSA Antibody (9A5) 可用于 ELISA。

Anti-ARSA Antibody (9A5)

还可以

产品编号 TMAY-00845

Anti-ARSA Antibody (9A5) 是一种 Rabbit 抗体，靶向 ARSA。Anti-ARSA Antibody (9A5) 可用于 ELISA。

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产品描述	Anti-ARSA Antibody (9A5) is a Rabbit antibody targeting ARSA. Anti-ARSA Antibody (9A5) can be used in ELISA.
Ig Type	Monoclonal Rabbit IgG
克隆号	9A5
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:1000-1:2000
抗体种类	Monoclonal
宿主来源	Rabbit
构建方式	This antibody was obtained from a rabbit immunized with purified, recombinant Human Arylsulfatase A / ARSA (rh Arylsulfatase A / ARSA; TMPY-00669; P15289-1; Met 1-Ala 507).
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Arylsulfatase A (ARSA) is synthesized as a 52KDa lysosomal enzyme. It is a member of the sulfatase family that is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet. Arylsulfatase A is activated by a required co- or posttranslational modification with the oxidation of cysteine to formylglycine. Metachromatic leukodystrophy (MLD) is a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms caused by the deficiency of Arylsulfatase A. Deficiency of this enzyme is also found in apparently healthy individuals, a condition for which the term pseudodeficiency is introduced. ARSA forms dimers after receiving three N-linked oligosaccharides in the endoplasmic reticulum, and then the dimers are transported to the Golgi where they receive mannose 6-phosphate recognition markers. And thus, ARSA is transported and delivered to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. It has been shown that within the lysosomes, the ARSA dimers can oligomerize to an octamer in a pH-dependent manner. The ARSA deficiency leads to metachromatic leucodystrophy (MLD), a lysosomal storage disorder associated with severe and progressive demyelination in he central and peripheral nervous system. Additionally, the serum level of arylsulfatase A might be helpful in diagnosis of lung and central nervous system cancer.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human Arylsulfatase A / ARSA protein (TMPY-00669)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.