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Anti-APC Antibody (2Z81)
还可以产品编号 TMAH-00068
别名 Protein APC, DP2.5, Deleted in polyposis 2.5, Adenomatous polyposis coli protein
Anti-APC Antibody (2Z81) 是一种抗体，靶向 APC。Anti-APC Antibody (2Z81) 可用于 ELISA, WB, IHC。
Anti-APC Antibody (2Z81)
Anti-APC Antibody (2Z81)
还可以产品编号 TMAH-00068 别名 Protein APC, DP2.5, Deleted in polyposis 2.5, Adenomatous polyposis coli protein
Anti-APC Antibody (2Z81) 是一种抗体，靶向 APC。Anti-APC Antibody (2Z81) 可用于 ELISA, WB, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-APC Antibody (2Z81) is an antibody targeting APC. Anti-APC Antibody (2Z81) can be used in ELISA, WB, IHC. |
| 别名 | Protein APC, DP2.5, Deleted in polyposis 2.5, Adenomatous polyposis coli protein |
| Ig Type | Rabbit IgG |
| 克隆号 | 2Z81 |
| 交叉反应 | Human, Rat |
| 验证活性 | 1. Western Blot -Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate -All lanes: APC antibody at 1:1000 -Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution -Predicted band size: 312, 301, 309 kDa -Observed band size: 160 kDa 2. IHC image of TMAH-00068 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, WB, IHC |
| 推荐剂量 | WB:1:500-1:5000; IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cell junction, adherens junction. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm. Cell membrane. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human APC |
| 抗原种属 | Human |
| 基因ID | 324 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Neuroscience, Cancer, Cardiovascular, Cell biology, Stem cells |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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