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Anti-Aminoacylase 1 Antibody (4C99)
还可以产品编号 TMAY-00962
Anti-Aminoacylase 1 Antibody (4C99) 是一种 Mouse 抗体，靶向 Aminoacylase 1。Anti-Aminoacylase 1 Antibody (4C99) 可用于 IHC-P。
Anti-Aminoacylase 1 Antibody (4C99)
Anti-Aminoacylase 1 Antibody (4C99)
还可以产品编号 TMAY-00962
Anti-Aminoacylase 1 Antibody (4C99) 是一种 Mouse 抗体，靶向 Aminoacylase 1。Anti-Aminoacylase 1 Antibody (4C99) 可用于 IHC-P。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Aminoacylase 1 Antibody (4C99) is a Mouse antibody targeting Aminoacylase 1. Anti-Aminoacylase 1 Antibody (4C99) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4C99 |
| 交叉反应 | Human |
| 验证活性 | Immunochemical staining of human ACY1 in human kidney with mouse monoclonal antibody (1:60, formalin-fixed paraffin embedded sections). Positive staining was localized to nephric tubule. |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:50-1:200 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ACY1 / Aminoacylase-1 (rh ACY1 / Aminoacylase-1; TMPY-01058; NP_000657.1; Met1-Ser408). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Aminoacylase 1 (ACY1), a metalloenzyme that removes amide-linked ACY1 groups from amino acids and may play a role in regulating responses to oxidative stress. Both the C-terminal fragment found in the two-hybrid screen and full-length ACY1 co-immunoprecipitate with SphK1. Though both C-terminal and full-length proteins slightly reduce SphK1 activity measured in vitro, the C-terminal fragment inhibits while full-length ACY1 potentiates the effects of SphK1 on proliferation and apoptosis. It suggested that ACY1 physically interacts with SphK1 and may influence its physiological functions. As a homodimeric zinc-binding enzyme, Aminoacylase 1 catalyzes the hydrolysis of N alpha-acylated amino acids. Deficiency of Aminoacylase 1 due to mutations in the Aminoacylase 1 (ACY1) gene follows an autosomal-recessive trait of inheritance and is characterized by accumulation of N-acetyl amino acids in the urine. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ACY1 / Aminoacylase-1 protein (TMPY-01058) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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