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Anti-ALK-4/ACVR1B Antibody (3Y53)
还可以产品编号 TMAY-00990
Anti-ALK-4/ACVR1B Antibody (3Y53) 是一种 Mouse 抗体，靶向 ALK-4/ACVR1B。Anti-ALK-4/ACVR1B Antibody (3Y53) 可用于 ELISA。
Anti-ALK-4/ACVR1B Antibody (3Y53)
Anti-ALK-4/ACVR1B Antibody (3Y53)
还可以产品编号 TMAY-00990
Anti-ALK-4/ACVR1B Antibody (3Y53) 是一种 Mouse 抗体，靶向 ALK-4/ACVR1B。Anti-ALK-4/ACVR1B Antibody (3Y53) 可用于 ELISA。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-ALK-4/ACVR1B Antibody (3Y53) is a Mouse antibody targeting ALK-4/ACVR1B. Anti-ALK-4/ACVR1B Antibody (3Y53) can be used in ELISA. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 3Y53 |
| 交叉反应 | Human |
| 应用 | ELISA |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ALK4 extracellular domain (rh ALK4; TMPY-01293; NP_004293.1; Met 1-Glu 126). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human ALK4 protein (TMPY-01293) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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