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Anti-14-3-3 sigma Antibody (4U743)
还可以产品编号 TMAY-01246
Anti-14-3-3 sigma Antibody (4U743) 是一种 Mouse 抗体，靶向 14-3-3 sigma。Anti-14-3-3 sigma Antibody (4U743) 可用于 FCM。
Anti-14-3-3 sigma Antibody (4U743)
Anti-14-3-3 sigma Antibody (4U743)
还可以产品编号 TMAY-01246
Anti-14-3-3 sigma Antibody (4U743) 是一种 Mouse 抗体，靶向 14-3-3 sigma。Anti-14-3-3 sigma Antibody (4U743) 可用于 FCM。
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偶联与修饰
抗原信息
| 产品描述 | Anti-14-3-3 sigma Antibody (4U743) is a Mouse antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody (4U743) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4U743 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human SFN expression on HeLa cells. Cells were stained with purified anti-Human SFN, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 14-3-3 sigma / Stratifin / YWHAS (rh 14-3-3 sigma / Stratifin / YWHAS; TMPY-01275; NP_006133.1; Met1-Ser248). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | 14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the 14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathways. More than 1 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | PE |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human 14-3-3 sigma / Stratifin / YWHAS Protein (TMPY-01275) |
| 抗原种属 | Human |
| 研究领域 | phospho-Serine/phospho-Threonine Binding Proteins, Adaptor Proteins, Apoptosis Adaptor Proteins |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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