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Ribavirin

产品编号 T0684 CAS 36791-04-5

别名: ICN-1229, Tribavirin, NSC-163039, RTCA, 利巴韦林

Ribavirin 是一种合成的呋喃核苷类似物，具有抗丙型肝炎病毒和其他 RNA 病毒的活性。

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Ribavirin, CAS 36791-04-5

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Ribavirin is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.
体内活性	ALT, AST activities and bilirubin levels are significantly loared by administration of JAT in combination with interferon and ribavirin (p<0.01). JAT, interferon or ribavirin alone with CCl4, livers appear to exhibit some liver protection against CCl4 as evident by the presence of normal hepatic cords, absence of necrosis and lesser fatty infiltration. Groups treated with JAT, Peg-interferon and ribavirin separately or in combination shows reduction in the expression of TGF- β and Bax. In the group treated by triple combination of interferon, ribavirin, and JAT, the expression level of p53 is markedly reduced[6]. Ribavirin capsules (400 mg of ribavirin)-treated Wistar rats show a significant decrease in activin-A and significant increase in follistatin at the serum and liver levels. Ribavirin has strong antiviral activity only when ribavirin is combined with either IFN-α or Peg-IFN-α[7]. Ribavirin (40 mg/kg, p.o.) significantly improves the antiviral efficacy of CM-10-18 in mice. Ribavirin inhibits DENV virus infection in cultured cells, but it is ineffective in reducing viremia in monotherapy[8].
细胞实验	The effect of Ribavirin on microglial cell viability is evaluated by the sulforhodamine B (SRB) chemosensitivity assay. Briefly, LPS-stimulated microglial cells are incubated for 48 h in the presence or absence of Ribavirin. Afterward, the cells are fixed in 10% (w/v) trichloroacetic acid for 1 h at 4°C, rinsed in tap water and stained with 0.4% (w/v) SRB in 1% acetic acid (100 μL/well) for 30 min at room temperature (RT). The cells are then rinsed three times in 1% acetic acid to remove the unbound stain. The protein bound stain is extracted with 200 μL 10 mM Tris base (pH 10.5) per well. The optical density is read at 540 nm, with correction at 670 nm. The results are presented as percentage of the control (non-stimulated/untreated microglial cells), that is arbitrarily set to 100%.

别名	ICN-1229, Tribavirin, NSC-163039, RTCA, 利巴韦林
分子量	244.2
分子式	C8H12N4O5
CAS No.	36791-04-5

存储

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

溶解度

H2O: 24.4 mg/mL (100 mM)

DMSO: 24.4 mg/mL (100 mM)

( < 1 mg/mL refers to the product slightly soluble or insoluble )

参考文献

1. Feld JJ, et al. Nature, 2005, 436(7053), 967-972. 2. Crotty S, et al. Nat Med, 2000, 6(12), 1375-1379. 3. Crotty S, et al. Proc Natl Acad Sci U S A, 2001, 98(12), 6895-6900. 4. Ning Q, et al. J Immunol, 1998, 160(7), 3487-3493. 5. Graci JD et al. Rev Med Virol, 2006, 16(1), 37-48. 6. Refaat B, et al. The effects of pegylated interferon-α and ribavirin on liver and serum concentrations of activin-A and follistatin in normal Wistar rat: a preliminary report. BMC Res Notes. 2015 Jun 26;8:265 7. Abdel-Hamid NM, et al. Synergistic Effects of Jerusalem Artichoke in Combination with Pegylated Interferon Alfa-2a and Ribavirin Against Hepatic Fibrosis in Rats. Asian Pac J Cancer Prev. 2016;17(4):1979-85. 8. Chen L, Hao Y, Song H, et al. Design, Synthesis, Characterization, and Biological Activities of Novel Spirooxindole Analogues Containing Hydantoin, Thiohydantoin, Urea, and Thiourea Moieties[J]. Journal of Agricultural and Food Chemistry. 2020, 68(39): 10618-10625. 9. Suroengrit A, Yuttithamnon W, Srivarangkul P, et al. Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity[J]. Scientific Reports. 2017 Oct 20;7(1):13696 10. Srivarangkul P, Yuttithamnon W, Suroengrit A, et al. A novel flavanone derivative inhibits dengue virus fusion and infectivity[J]. Antiviral research. 2018 Mar;151:27-38.

文献引用

1. Xu W, Yang R, Hao Y, et al. Discovery of Aldisine and Its Derivatives as Novel Antiviral, Larvicidal, and Antiphytopathogenic-Fungus Agents. Journal of Agricultural and Food Chemistry. 2022 2. Cheng N, Jiang N, Fu Y, et al. The mechanism and pharmacodynamics of 2-((1H-indol-3-yl) thio/sulfinyl)-N-pheny acetamide derivative as a novel inhibitor against human respiratory syncytial virus. Journal of Enzyme Inhibition and Medicinal Chemistry. 2022, 37(1): 2598-2604 3. Suroengrit A, Yuttithamnon W, Srivarangkul P, et al. Halogenated Chrysins Inhibit Dengue and Zika Virus Infectivity. Scientific Reports. 2017, 7(1): 1-11 4. Cui P, Cai M, Meng Y, et al. Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety. Scientific Reports. 2022, 12(1): 1-10. 5. Srivarangkul P, Yuttithamnon W, Suroengrit A, et al. A novel flavanone derivative inhibits dengue virus fusion and infectivity. Antiviral Research. 2018 Mar;151:27-38 6. Chen L, Hao Y, Song H, et al. Design, Synthesis, Characterization, and Biological Activities of Novel Spirooxindole Analogues Containing Hydantoin, Thiohydantoin, Urea, and Thiourea Moieties. Journal of Agricultural and Food Chemistry. 2020, 68(39): 10618-10625. 7. Kanyaboon P, Saelee T, Suroengrit A, et al. Cardol triene inhibits dengue infectivity by targeting kl loops and preventing envelope fusion. Scientific Reports. 2018 Nov 9;8(1):16643 8. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019 9. Fu Y H, Xu Z X, Jiang N, et al. High-throughput screening of active compounds against human respiratory syncytial virus. Virology. 2019 10. Xu W, Yang R, Liu L, et al.Design, Synthesis, and Bioactivity of Aldisine Derivatives Containing Oxime and Hydrazine Moieties Based on Hydrogen Bonds.Journal of Agricultural and Food Chemistry.2023

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

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技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Ribavirin 36791-04-5 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Microbiology/Virology Neuroscience Proteases/Proteasome Dehydrogenase HCV Protease DNA/RNA Synthesis Antibiotic AChR RSV ICN-1229 Respiratory syncytial virus ICN 1229 Inhibitor HCV inhibit ICN1229 Tribavirin Orthopoxvirus NSC-163039 RTCA Hepatitis C virus 利巴韦林 inhibitor

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Ribavirin

存储

溶解度

参考文献

文献引用

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剂量换算

体内实验配液计算器

计算器

输入分子式，点击计算，可计算出产品的分子量。

技术支持

Keywords