Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Norverapamil hydrochloride (D591 hydrochloride) 是 Verapamil 的 N-去甲基代谢物,是 L 型钙通道阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 538 | 现货 | ||
2 mg | ¥ 788 | 现货 | ||
5 mg | ¥ 1,280 | 现货 | ||
10 mg | ¥ 2,120 | 现货 | ||
25 mg | ¥ 3,590 | 现货 | ||
50 mg | ¥ 5,220 | 现货 | ||
100 mg | ¥ 7,370 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,330 | 现货 |
产品描述 | Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. |
体外活性 | Norverapamil also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil. Verapamil and its major metabolite Norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in the clinic. Norverapamil hydrochloride ((±)-Norverapamil hydrochloride) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs [1][3]. |
体内活性 | Norverapamil hydrochloride (9 mg/kg; p.o.) has a terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng?h/ml, and 41.6 ng/mL, respectively[4]. |
别名 | (±)-Norverapamil hydrochloride, D591 hydrochloride, 盐酸去甲维拉帕米 |
分子量 | 477.04 |
分子式 | C26H37ClN2O4 |
CAS No. | 67812-42-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (104.81 mM)
DMSO: 31 mg/mL (64.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.0963 mL | 10.4813 mL | 20.9626 mL | 52.4065 mL |
5 mM | 0.4193 mL | 2.0963 mL | 4.1925 mL | 10.4813 mL | |
10 mM | 0.2096 mL | 1.0481 mL | 2.0963 mL | 5.2407 mL | |
20 mM | 0.1048 mL | 0.5241 mL | 1.0481 mL | 2.6203 mL | |
50 mM | 0.0419 mL | 0.2096 mL | 0.4193 mL | 1.0481 mL | |
H2O | 100 mM | 0.021 mL | 0.1048 mL | 0.2096 mL | 0.5241 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Norverapamil hydrochloride 67812-42-4 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel P-gp Drug Metabolite MDR1 CD243 Inhibitor mycobacterial Norverapamil M. tuberculosis Multidrug resistance protein 1 D 591 Hydrochloride Ca2+ channels metabolite (±)-Norverapamil D-591 Hydrochloride efflux D591 Hydrochloride Ca channels P-glycoprotein inhibit Norverapamil Hydrochloride ABCB1 Cluster of differentiation 243 (±)-Norverapamil hydrochloride D 591 pumps D591 hydrochloride D-591 盐酸去甲维拉帕米 D591 Pgp inhibitor