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KL001

Name: KL001
Brand: TargetMol
SKU: T22891
Price: 328 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.22%

货号 T22891Cas号 309928-48-1

别名 KL-001, KL 001

KL001 是一流的隐花色素蛋白 (CRY)稳定剂，可与 CRY1 和 CRY2 特异性相互作用。其中CRY 是一种对蓝光敏感的黄素蛋白，参与调节动植物的昼夜节律。KL001能够防止泛素依赖性 CRY 降解，从而延长了昼夜节律周期，具有控制空腹激素诱导的糖异生的潜力。

为众多的药物研发团队赋能，

让新药发现更简单！

KL001

一键复制产品信息

很棒

纯度: 99.22%

货号 T22891 别名 KL-001, KL 001Cas号 309928-48-1

规格	价格	库存
1 mg	¥ 328	现货
5 mg	¥ 712	现货
10 mg	¥ 1,090	现货
25 mg	¥ 1,950	现货
50 mg	¥ 2,970	现货
100 mg	¥ 4,380	现货
200 mg	¥ 6,180	现货
1 mL x 10 mM (in DMSO)	¥ 623	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

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纯度: 99.22%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

KL001 AI Summary

KL001 exhibits a diverse range of bioactivities across various assays and targets. It has been identified as having agonist activity for the Thyroid Stimulating Hormone Receptor and inhibitory activity against Cruzain and several other targets, including Influenza NS1 Protein, JMJD2A-Tudor Domain, Nrf2, GCN5L2, Histone Lysine Methyltransferase G9a, BAZ2B, Thioredoxin Reductase 1, malarial parasite plastid, Lassa Virus, Marburg Virus, GLP-1 Receptor, Pin1, and USP1/UAF1 complex. Additionally, it has shown modulation of lipid storage in Drosophila S3 Cells and promotion of Anthrax Lethal Toxin internalization. In human U2OS cells harboring Per2-dLuc luciferase reporter gene, it demonstrated bioactivity in reducing PER2 amplitude effect with an EC50 of 870.0 nM, suggesting potential in circadian rhythm regulation. It also shows modulation activity at CRY2/PER2 with an EC50 of 870.0 nM and demonstrated a stronger activity on Cry1/Cry2 with an EC50 of 340.0 nM in the same cell type. In HEK293 cells, it showed an EC50 of 9410.0 nM for modulating C-terminal FLAG3-tagged CRY1. For its antiviral activity, KL001 inhibited SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells, though with varying effectiveness, and exhibited moderate inhibition of the SARS-CoV-2 3CL-Pro protease at 20µM. Additionally, it showed mild inhibitory activity against human HDAC6 in enzymatic assays. These activities highlight the compound's potential for therapeutic applications in various diseases, including viral infections and circadian rhythm disorders..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
别名	KL-001, KL 001

化学信息

分子量	398.48
分子式	C₂₁H₂₂N₂O₄S
CAS No.	309928-48-1
Smiles	CS(=O)(=O)N(CC(O)Cn1c2ccccc2c2ccccc12)Cc1ccco1
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 65 mg/mL (163.12 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.51 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5095 mL	12.5477 mL	25.0954 mL	125.4768 mL
5 mM	0.5019 mL	2.5095 mL	5.0191 mL	25.0954 mL
10 mM	0.2510 mL	1.2548 mL	2.5095 mL	12.5477 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2738 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5095 mL
100 mM	0.0251 mL	0.1255 mL	0.2510 mL	1.2548 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。