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顶部相关产品产品介绍化学信息储存和溶解信息计算器

Glutathione oxidized

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纯度: 99.88%

货号 T1085LCas号 27025-41-8

别名 氧化型谷胱甘肽, Oxidized glutathione, L-谷胱甘肽(氧化型), L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)

Glutathione oxidized (L(-)-Glutathione) 是氧化型谷胱甘肽，谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。Glutathione oxidized 可用于镰状细胞和红细胞的研究。

Glutathione oxidized
其他形式的 “Glutathione oxidized”:
Glutathione oxidized-13C4,15N2
L-Glutathione, oxidized (sodium salt)

Glutathione oxidized

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纯度: 99.88%

货号 T1085L 别名 氧化型谷胱甘肽, Oxidized glutathione, L-谷胱甘肽(氧化型), L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)Cas号 27025-41-8

Glutathione oxidized (L(-)-Glutathione) 是氧化型谷胱甘肽，谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。Glutathione oxidized 可用于镰状细胞和红细胞的研究。

规格价格库存数量
50 mg
¥ 136
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100 mg
¥ 183
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500 mg
¥ 372
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1 g
¥ 447
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1 mL x 10 mM (in H2O)
¥ 150
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产品介绍

Glutathione oxidized AI Summary
Glutathione oxidized exhibits a range of inhibitory activities across different biological systems and assays. It shows potent inhibitory activity against glutathione reductase in the presence of NADPH, with a Km value of 114,700.0 nM. The compound also modulates human MRP2-mediated estradiol-17-beta-glucuronide transport with an activity level of 136.0% relative to control in Sf9 cells inverted membrane vesicles and inhibits MRP1 with a Km value of 93,000.0 nM. Additionally, Glutathione oxidized acts as an inhibitor in various bioassays: it inhibits Tau fibril formation and Thioflavin T binding with potencies ranging from 19,952.6 nM to 39,810.7 nM; Bacillus subtilis Sfp phosphopantetheinyl transferase with potencies from 44,668.4 nM to 100,000.0 nM; and fructose-1,6-bisphosphate aldolase from Giardia Lamblia with a potency of 1,990.5 nM. It also inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells, with a potency of 23,715.0 nM. In antibacterial applications, Glutathione oxidized shows activity against both metronidazole-resistant and metronidazole-susceptible strains of Helicobacter pylori, with varying Km values indicating higher affinity in the susceptible strains (ranging from 2,300,000 nM to 4,900,000 nM) compared to the resistant ones (ranging from 3,000,000 nM to 5,200,000 nM). However, Glutathione oxidized exhibits no measurable inhibitory activity against wild type recombinant human histone lysine methyltransferase G9a or GLP, with an IC50 value greater than 100,000.0 nM for both enzymes. Lastly, it demonstrated bioactivity in reducing cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), with an inhibition index of 1.297, surpassing the activity of the control (arbidol)..
Note: Summary generated by AI. Data source: ChEMBL
生物活性
产品描述
Glutathione oxidized (L(-) -glutathione) is the oxidized form of Glutathione, which is a major antioxidant and antidote in cells. Glutathione oxidized can be used to study sickle cells and red blood cells.
靶点活性
[3H]-AMPA:0.8-15.9 μM
体外活性

方法： 镰状红细胞用Glutathione oxidized（10 μmol/L）处理0、90、150、210分钟检测细胞内外GSH浓度差。
结果：Glutathione oxidized 的外排增加导致谷胱甘肽耗竭，并可能削弱镰状红细胞的抗氧化防御。[1]

体内活性

方法：为研究Glutathione oxidized对脑损伤的影响，将Glutathione oxidized（100 mM）注射给给野生小鼠。
结果：Glutathione oxidized在野生型小鼠中引起明显的脑损伤。[2]

别名氧化型谷胱甘肽, Oxidized glutathione, L-谷胱甘肽(氧化型), L-Glutathione oxidized, L(-)-Glutathione, GSSG, Glutathione disulfide, Bi(glutathion-S-yl)
化学信息
分子量612.63
分子式C20H32N6O12S2
CAS No.27025-41-8
Smiles[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CSSC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
密度1.54g/cm3
颜色White
物理性状Solid
储存&溶解度
存储keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
溶解度信息
DMSO: 1.39 mg/mL (2.27 mM), Sonication is recommended.
H2O: 165 mg/mL (269.33 mM), Sonication is recommended.
溶液配制表
DMSO/H2O
1mg5mg10mg50mg
1 mM1.6323 mL8.1615 mL16.3231 mL81.6153 mL
H2O
1mg5mg10mg50mg
5 mM0.3265 mL1.6323 mL3.2646 mL16.3231 mL
10 mM0.1632 mL0.8162 mL1.6323 mL8.1615 mL
20 mM0.0816 mL0.4081 mL0.8162 mL4.0808 mL
50 mM0.0326 mL0.1632 mL0.3265 mL1.6323 mL
100 mM0.0163 mL0.0816 mL0.1632 mL0.8162 mL

计算器

  • 摩尔浓度 计算器
  • 稀释 计算器
  • 配液 计算器
  • 分子量 计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
TargetMol | Animal experiments 比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments 一共给药动物10只，您使用的配方为5%TargetMol | reagent DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline/PBS/ddH2O， 那么您的工作液浓度为2mg/mL。
母液配置方法: 2 mg 药物溶于 50 μLDMSOTargetMol | reagent （ 母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。
体内配方的制备方法: 取 50μLDMSOTargetMol | reagent 母液，添加 300 μLPEG300TargetMol | reagent 混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline/PBS/ddH2OTargetMol | reagent 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ， 玉米油 等， 均可在TargetMol网站点击购买。
1 请输入动物实验的基本信息
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2 请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。
% DMSO
%
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% Saline/PBS/ddH2O

剂量转换

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关键词

ReactiveOxygenSpeciesReactive Oxygen SpeciesOxiglutationeLGlutathioneInhibitorinhibitGlutathionereductaseGlutathione reductaseGlutathione oxidizedGlutathione DisulfideGlutathioneEndogenousMetaboliteEndogenous Metabolite
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