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Favipiravir

Favipiravir

产品编号 T6833   CAS 259793-96-9
别名: T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, 法匹拉韦, 法维拉韦

Favipiravir (T-705) 是一种有效且选择性的 RNA 依赖性 RNA 聚合酶抑制剂,用于治疗流感病毒感染。

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Favipiravir Chemical Structure
Favipiravir, CAS 259793-96-9
规格 价格/CNY 货期 数量
5 mg ¥ 659 现货
10 mg ¥ 1,177 现货
50 mg ¥ 2,890 现货
100 mg ¥ 3,990 现货
500 mg ¥ 8,890 现货
1 mL * 10 mM (in DMSO) ¥ 728 现货
其他形式的 Favipiravir:
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
MG-132限时半价
产品目录号及名称: Favipiravir (T6833)
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选择批次  
纯度: 100%
纯度: 100%
纯度: 99.30%
纯度: 98.16%
更多批次查询请联系客服
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
靶点活性 RdRP:341 nM.
体外活性 Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]
体内活性 In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]
细胞实验 The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)
别名 T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, 法匹拉韦, 法维拉韦
化合物与蛋白结合的复合物

T6833_2

Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP

分子量 157.1
分子式 C5H4FN3O2
CAS No. 259793-96-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 12 mg/mL(76.4 mM)

H2O: 5 mg/mL (31.82 mM)

DMSO: 29 mg/mL (184.6 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / H2O / DMSO 1 mM 6.3654 mL 31.8269 mL 63.6537 mL 159.1343 mL
5 mM 1.2731 mL 6.3654 mL 12.7307 mL 31.8269 mL
10 mM 0.6365 mL 3.1827 mL 6.3654 mL 15.9134 mL
20 mM 0.3183 mL 1.5913 mL 3.1827 mL 7.9567 mL
Ethanol / DMSO 50 mM 0.1273 mL 0.6365 mL 1.2731 mL 3.1827 mL
DMSO 100 mM 0.0637 mL 0.3183 mL 0.6365 mL 1.5913 mL

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TargetMol Library Books参考文献

1. Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981. 2. Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751. 3. Madelain V, et al. Antiviral Res. 2015, 123, 70-77. 4. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643. 5. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.

TargetMol Library Books文献引用

1. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 2. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504 3. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643 4. Zhang J, He M, Xie Q, et al.Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity.ACS Omega.2022 5. Westover J B, Jung K H, Alkan C, et al.Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine.Journal of Virology.2024: e00132-24.
Mefloquine hydrochloride Simeprevir SARS-CoV-2-IN-49 Tipranavir Ritonavir Camostat mesylate SARS-CoV-2-IN-50 SARS-CoV-2-IN-43

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 抗癌临床化合物库 抗癌上市药物库 抑制剂库 药物功能重定位化合物库 FDA上市及药典收录分子库 上市药物库 抗COVID-19化合物库 经典已知活性库 临床期小分子药物库

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请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

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Keywords

Favipiravir 259793-96-9 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others SARS-CoV Influenza Virus DNA/RNA Synthesis inhibit T705 SARS coronavirus T-705 Inhibitor T 705 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide 法匹拉韦 法维拉韦 inhibitor

 

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