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Favipiravir

规格	价格/CNY		数量
5 mg	￥ 659	现货
10 mg	￥ 1,177	现货
50 mg	￥ 2,890	现货
100 mg	￥ 3,990	现货
500 mg	￥ 8,890	现货
1 mL * 10 mM (in DMSO)	￥ 728	现货

相关产品

产品描述	Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
靶点活性	RdRP:341 nM.
体外活性	Favipiravir展示了对抗流感病毒的活性，对A型流感病毒的IC50范围为0.013至0.48 μg/ml，对B型流感病毒的IC50范围为0.039至0.089 μg/ml，对C型流感病毒的IC50范围为0.030至0.057 μg/ml。在哺乳动物细胞系（MDCK细胞、Vero细胞、HEL细胞、A549细胞、HeLa细胞及HEp-2细胞）中，Favipiravir在高达1,000 μg/ml的浓度下未显示出细胞毒性。[1]在接种季节性流感A（H1N1）病毒的MDCK细胞中，Favipiravir诱导致命性突变。[2]
体内活性	在流感病毒感染的小鼠中，Favipiravir (200 mg/kg/day, p.o.) 可保护小鼠免受流感病毒感染导致的死亡。[1] 在实验室感染埃博拉病毒的小鼠中，Favipiravir 有效阻止病毒增殖，在治疗开始后的第2天和第6天，抗病毒效果分别达到95%和99.6%。[3]
细胞实验	The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)

别名	T-705, 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, 法匹拉韦, 法维拉韦
化合物与蛋白结合的复合物	Nsp7-Nsp8-Nsp12 SARS-CoV2 RNA-dependent RNA polymerase in complex with template:primer dsRNA and favipiravir-RTP
分子量	157.1
分子式	C5H4FN3O2
CAS No.	259793-96-9

存储

|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 12 mg/mL (76.4 mM)

H2O: 5 mg/mL (31.82 mM)

DMSO: 45 mg/mL (286.44 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
Ethanol / H2O / DMSO	1 mM	6.3654 mL	31.8269 mL	63.6537 mL	159.1343 mL
	5 mM	1.2731 mL	6.3654 mL	12.7307 mL	31.8269 mL
	10 mM	0.6365 mL	3.1827 mL	6.3654 mL	15.9134 mL
	20 mM	0.3183 mL	1.5913 mL	3.1827 mL	7.9567 mL
Ethanol / DMSO	50 mM	0.1273 mL	0.6365 mL	1.2731 mL	3.1827 mL
DMSO	100 mM	0.0637 mL	0.3183 mL	0.6365 mL	1.5913 mL

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参考文献

1. Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981. 2. Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751. 3. Madelain V, et al. Antiviral Res. 2015, 123, 70-77. 4. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses[J]. Frontiers in Microbiology. 2018 Nov 6;9:2643. 5. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504.

文献引用

1. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 2. Qiu M, Li Z, Chen Y, et al. Tolcapone Potently Inhibits Seminal Amyloid Fibrils Formation and Blocks Entry of Ebola Pseudoviruses. Frontiers in Microbiology. 2020, 11: 504 3. WEI X U, Shuai X, Jing P, et al. The antihistamine drugs carbinoxamine maleate and chlorpheniramine maleate exhibit potent antiviral activity against a broad spectrum of influenza viruses. Frontiers in Microbiology. 2018 Nov 6;9:2643 4. Zhang J, He M, Xie Q, et al.Predicting In Vitro and In Vivo Anti-SARS-CoV-2 Activities of Antivirals by Intracellular Bioavailability and Biochemical Activity.ACS Omega.2022 5. Westover J B, Jung K H, Alkan C, et al.Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine.Journal of Virology.2024: e00132-24.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

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第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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