Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cefoxitin (Rephoxitin) 是一种广谱的、可口服的第二代头孢霉素类抗生素。Cefoxitin 干扰细菌细胞壁的合成。其活性谱包括革兰氏阴性和革兰氏阳性菌,通常用于腹腔感染、盆腔感染和某些类型的妇科感染等腹部,对厌氧菌具有高效性。
产品描述 | Cefoxitin (Rephoxitin) is a broad-spectrum, orally available second-generation cephalosporins antibiotic. Cefoxitin interferes with the synthesis of bacterial cell walls. Its activity profile includes Gram-negative and Gram-positive bacteria, and is commonly used in abdominal cavity infections, pelvic infections, and certain types of gynecological infections, and is highly effective against anaerobic bacteria. |
靶点活性 | PBP2b:0.19 μg/mL, PBP5:0.19 μg/mL, PBP4:0.14 μg/mL, PBP3:1.04 μg/mL, PBP2a:0.72 μg/mL |
体外活性 |
Cefoxitin has good activity against Gram-positive bacteria. The MICs for several Gram-positive pathogens are in the range of 1-6 μg/mL[1]. Cefoxitin (1.25 µM/mL) exhibits high efficacy killing B. burgdorferi at concentration [2]. |
体内活性 | Cefoxitin administration at a dose of 20 mg/kg via intraperitoneal injection for 5 consecutive days demonstrates effective eradication of B. burgdorferi in the C3H/HeN mouse model.[2] |
别名 | Rephoxitin, Cefoxitinum |
分子量 | 427.45 |
分子式 | C16H17N3O7S2 |
CAS No. | 35607-66-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (210.6 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3395 mL | 11.6973 mL | 23.3945 mL | 58.4864 mL |
5 mM | 0.4679 mL | 2.3395 mL | 4.6789 mL | 11.6973 mL | |
10 mM | 0.2339 mL | 1.1697 mL | 2.3395 mL | 5.8486 mL | |
20 mM | 0.117 mL | 0.5849 mL | 1.1697 mL | 2.9243 mL | |
50 mM | 0.0468 mL | 0.2339 mL | 0.4679 mL | 1.1697 mL | |
100 mM | 0.0234 mL | 0.117 mL | 0.2339 mL | 0.5849 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cefoxitin 35607-66-0 Immunology/Inflammation Microbiology/Virology Cell wall Antibacterial Antibiotic Rephoxitin Cefoxitinum Inhibitor inhibitor inhibit