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2-Iodohippuric Acid

Name: 2-Iodohippuric Acid
Brand: TargetMol
SKU: T50000
Price: 110 CNY
Availability: InStock
Rating: 5 (10 reviews)

货号 T50000Cas号 147-58-0 一键复制产品信息纯度: 99.26%

很棒

2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究，也用于某些疾病的诊断，如肝病和肾病。此外，它还用于某些药物的合成。

2-Iodohippuric Acid

一键复制产品信息

很棒

纯度: 99.26%

货号 T50000Cas号 147-58-0

2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究，也用于某些疾病的诊断，如肝病和肾病。此外，它还用于某些药物的合成。

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
5 mg	¥ 120	现货
10 mg	¥ 179	现货
25 mg	¥ 309	现货
50 mg	¥ 461	现货
100 mg	¥ 693	现货
200 mg	¥ 1,030	现货
1 mL x 10 mM (in DMSO)	¥ 110	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.26%

颜色: 白色

性状: Solid

资源下载: COA HNMR LCMS 产品操作手册

产品介绍

2-Iodohippuric Acid AI Summary

2-Iodohippuric Acid is a versatile bioactive compound with multiple mechanisms of action. It stimulates oxygen consumption through the activity of rat recombinant peptidylglycine alpha-amidating monooxygenase, with a Km value of 3400000.0 nM and a Vmax(app) of 3.1 /s, yielding a Vmax(app)/Km(app) ratio of 9.1 x 10^2/M/s. Additionally, it has an activity level of 0.1 compared to hippuric acid. This compound also modulates lamin A splicing and can block the entry of the Ebola virus, showing efficacy in both nanomolar and micromolar concentrations. Beyond these activities, 2-Iodohippuric Acid displays notable antiviral properties against SARS-CoV-2. It inhibits the cytotoxicity of Caco-2 cells by 4.42% at a 10 µM concentration after 48 hours, as determined by high content imaging. It also inhibits the SARS-CoV-2 3CL-Pro protease by 18.91% at a concentration of 20 µM measured via a FRET assay using a peptide substrate. The compound further shows an ability to inhibit SARS-CoV-2-induced cytotoxicity in VERO-6 cells with an inhibition rate of -0.01% at 10 µM concentration. Moreover, 2-Iodohippuric Acid inhibits human HDAC6 activity, showing 36.62% inhibition using a commercial peptide substrate and 10.74% inhibition using a custom peptide substrate in enzymatic assays. This profile outlines 2-Iodohippuric Acid as a promising candidate for further research in therapeutic applications related to viral infections and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	2-Iodohippuric Acid can be used to measure renal clearance for renal function studies, and for the diagnosis of certain diseases, such as liver and kidney disease. In addition, it is used in the synthesis of certain drugs.

化学信息

分子量	305.0692
分子式	C₉H₈INO₃
CAS No.	147-58-0
Smiles	OC(=O)CNC(=O)C1=CC=CC=C1I
密度	1.871g/cm3

储存&溶解度

存储

溶解度信息

DMSO: 55 mg/mL (180.29 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2779 mL	16.3897 mL	32.7794 mL	163.8972 mL
5 mM	0.6556 mL	3.2779 mL	6.5559 mL	32.7794 mL
10 mM	0.3278 mL	1.6390 mL	3.2779 mL	16.3897 mL
20 mM	0.1639 mL	0.8195 mL	1.6390 mL	8.1949 mL
50 mM	0.0656 mL	0.3278 mL	0.6556 mL	3.2779 mL
100 mM	0.0328 mL	0.1639 mL	0.3278 mL	1.6390 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。