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1-Methylimidazole

Name: 1-Methylimidazole
Brand: TargetMol
SKU: T0575
Price: 99 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 99.50%

货号 T0575Cas号 616-47-7

别名 N-甲基咪唑

1-Methylimidazole 是1-methyl-2-thioimidazole (methimazole)的代谢物，可抑制骨吸收。

1-Methylimidazole

一键复制产品信息

很棒

纯度: 99.50%

货号 T0575 别名 N-甲基咪唑Cas号 616-47-7

1-Methylimidazole 是1-methyl-2-thioimidazole (methimazole)的代谢物，可抑制骨吸收。

规格	价格	库存	数量
1 g	¥ 99	现货
1 mL x 10 mM (in DMSO)	¥ 99	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: 99.50%

颜色: 无色透明

性状: Liquid

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资源下载:

COA HNMR LCMS 产品操作手册

产品介绍

1-Methylimidazole AI Summary

1-Methylimidazole is a multi-functional bioactive compound with diverse properties and activities. It has a dissociation constant (pKa) of 7.12, indicating specific behaviors related to ionization and protonation at certain pH levels. It enhances styrene oxide hydrolase activity at pH 8.7, with an efficiency of E100 = 0.012 M, achieving maximum enhancement at a concentration of 0.05 M. Additionally, it enhances epoxide hydrolase activity with a Log 1/E100 value of 1.94 and has a partition coefficient (logP) value of 0.28. 1-Methylimidazole also exhibits germicidal activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes at a concentration of 254 ppm with a sterilization time of over 0.5 hours. It acts as an inhibitor of CYP3A4 with an IC50 value greater than 10,000 nM, indicating its role as a retinoic acid metabolism blocking agent (RAMBA). Moreover, it demonstrates inhibitory effects on the SARS-CoV-2 3CL-Pro protease with an inhibition rate of 21.78% at a 20 µM concentration and exhibits antiviral activity against SARS-CoV-2 by inhibiting virus-induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours of virus exposure. In cellular assays, 1-Methylimidazole acts as both an agonist and antagonist of the NFkB signaling pathway with a potency of 6.3 nM. It inhibits multiple enzymes including APE1, HADH2, Histone Lysine Methyltransferase G9a, FEN1, Human D2 Dopamine Receptor, and Arylsulfatase A with varying potencies from 794.3 nM to 37685.8 nM. Overall, 1-Methylimidazole shows potential in various biochemical and pharmacological applications due to its diverse bioactive properties..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	1-Methylimidazole is a metabolite of 1-methyl-2-thioimidazole (methimazole) which inhibits bone resorption.
别名	N-甲基咪唑

化学信息

分子量	82.10
分子式	C₄H₆N₂
CAS No.	616-47-7
Smiles	CN1C=CN=C1
密度	1.035 g/cm3. Temperature:20 °C.;1.017 g/cm3. Temperature:40 °C.

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 45 mg/mL (548.11 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	12.1803 mL	60.9013 mL	121.8027 mL	609.0134 mL
5 mM	2.4361 mL	12.1803 mL	24.3605 mL	121.8027 mL
10 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
20 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
50 mM	0.2436 mL	1.2180 mL	2.4361 mL	12.1803 mL
100 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法： 取 100 μL DMSO 母液，添加 400 μL PEG300 混匀澄清，再加 50 μL Tween 80, 混匀澄清, 再加 450 μL Saline / PBS / ddH₂O 混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO， PEG300， PEG400， Tween 80， SBE-β-CD，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

关键词

1-Methylimidazole 1Methylimidazole 1 Methylimidazole

1-Methylimidazole

1-Methylimidazole