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Chk

Chk

Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that, in humans, is encoded by the CHEK1 gene. Chk1 coordinates the DNA damage response (DDR) and cell cycle checkpoint response. Activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death to prevent damaged cells from progressing through the cell cycle.
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Cat. No. Product Name CAS No. Purity Chemical Structure
T10718L CCT241533 hydrochloride
化合物 T10718L
1431697-96-9 98%
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
TN1458 Buddlejasaponin IV
醉鱼草皂苷 Ⅳ
139523-30-1 98%
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
T17223 VER-00158411
化合物 T17223
1174664-88-0 98%
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
T16165 Myriocin
多球壳菌素
35891-70-4 98%
Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物,是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性,通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染...
T10790 CHK1-IN-2
化合物 T10790
912367-45-4 98%
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
T16848 SB-218078
化合物 T16848
135897-06-2 98%
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
T10793 CHK1 inhibitor
化合物 T10793
2097938-64-0 98%
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
T10718 CCT241533
化合物 T10718
1262849-73-9 98%
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
T14904 CCT244747
化合物 T14904
1404095-34-6 98%
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
T10792 CHK1-IN-4
化合物 T10792
2120398-41-4 98%
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
T11960 MBM-55
化合物MBM-55
2083622-09-5 99.98%
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
T3700 SCH900776 (S-isomer)
化合物SCH900776 S-isomer
891494-64-7 99.95%
SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。
T10406 Tuvusertib
化合物Tuvusertib
1613200-51-3 99.66%
Tuvusertib (M1774) 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂(Ki< 1 µΜ),具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性,阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK1)的下游磷酸化,从而抑制 DNA 损伤检查点激活,破坏 DNA ...
T6931 PD0166285
化合物PD0166285
185039-89-8 99.59%
PD0166285是 P-gp 的底物,是一种有效的 Wee1 和 Chk1 抑制剂弱抑制。
T6084 Rabusertib
化合物Rabusertib
911222-45-2 99.40%
Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂,IC50为 7 nM。它有潜在的化学增强活性,用于各种癌症和肿瘤治疗的试验。
T1837 BX-912
化合物BX912
702674-56-4 99.34%
BX-912 是一种直接的,选择性的,ATP 竞争性的PDK1抑制剂,IC50值为 26 nM。它阻断肿瘤细胞 PDK1/Akt 信号转导,抑制多种肿瘤细胞株的锚定依赖性生长或诱导凋亡。
T10325 ANI-7
化合物ANI-7
931417-26-4 99.21%
ANI-7是芳香烃受体(AhR)途径的激活剂。ANI-7抑制多种癌症细胞的生长,并有效且选择性地抑制MCF-7乳腺癌症细胞的生长(GI50:0.56μM)。
T6093 AZD-7762
化合物AZD7762
860352-01-8 99.17%
AZD-7762 是一种有效的 ATP 竞争性的细胞周期检测点激酶抑制剂,抑制 Chk1的 IC50为 5 nM。
T4327 Prexasertib dihydrochloride
化合物Prexasertib dihydrochloride
1234015-54-3 99.17%
Prexasertib dihydrochloride (LY2606368) 是一种选择性的,ATP 竞争性的细胞周期检测点激酶 1 抑制剂,Ki 为 0.9 nM,IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变,导致细胞凋亡,有...
T2033 BML-277
化合物BML-277
516480-79-8 99.09%
BML-277 (C 3742) 是一种选择性的检测点激酶 2 抑制剂,IC50为 15 nM。
CCT241533 hydrochloride
T10718L
CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
Buddlejasaponin IV
TN1458
Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-ka...
VER-00158411
T17223
VER-00158411 is a checkpoint kinase 1 and CHK2 inhibitor (IC50: 4.4 nM and 4.5 nM, respectively).
Myriocin
T16165
Myriocin (Thermozymocidin) 是一种从 Myriococcum albomyces 中得到的代谢产物,是一种丝氨酸-棕榈酰转移酶 (SPT) 抑制剂,具有潜在的抗肿瘤抗癌和抗寄生虫活性,通过 PI3K/Akt/mTOR 通路调节巨噬细胞极化和功能来抑制肿瘤生长。Myriocin 抑制 HCV 感染...
CHK1-IN-2
T10790
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM).
SB-218078
T16848
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 i...
CHK1 inhibitor
T10793
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor.
CCT241533
T10718
CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).
CCT244747
T14904
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM).
CHK1-IN-4
T10792
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity.
MBM-55
T11960
MBM-55 是一种有效的中心体相关激酶 2 (NEK2) 抑制剂,IC50 为 1 nM。 MBM-55 通过诱导细胞周期停滞和凋亡有效抑制癌细胞的增殖。
SCH900776 (S-isomer)
T3700
SCH900776 S-isomer (MK-8776 S-isomer) 是SCH900776的S 型同分异构体。
Tuvusertib
T10406
Tuvusertib (M1774) 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂(Ki< 1 µΜ),具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性,阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK1)的下游磷酸化,从而抑制 DNA 损伤检查点激活,破坏 DNA ...
PD0166285
T6931
PD0166285是 P-gp 的底物,是一种有效的 Wee1 和 Chk1 抑制剂弱抑制。
Rabusertib
T6084
Rabusertib (IC-83) 是一种有效的选择性的Chk1抑制剂,IC50为 7 nM。它有潜在的化学增强活性,用于各种癌症和肿瘤治疗的试验。
BX-912
T1837
BX-912 是一种直接的,选择性的,ATP 竞争性的PDK1抑制剂,IC50值为 26 nM。它阻断肿瘤细胞 PDK1/Akt 信号转导,抑制多种肿瘤细胞株的锚定依赖性生长或诱导凋亡。
ANI-7
T10325
ANI-7是芳香烃受体(AhR)途径的激活剂。ANI-7抑制多种癌症细胞的生长,并有效且选择性地抑制MCF-7乳腺癌症细胞的生长(GI50:0.56μM)。
AZD-7762
T6093
AZD-7762 是一种有效的 ATP 竞争性的细胞周期检测点激酶抑制剂,抑制 Chk1的 IC50为 5 nM。
Prexasertib dihydrochloride
T4327
Prexasertib dihydrochloride (LY2606368) 是一种选择性的,ATP 竞争性的细胞周期检测点激酶 1 抑制剂,Ki 为 0.9 nM,IC50为 <1 nM。它抑制 CHK2(IC50=8 nM) 和 RSK1 (IC50=9 nM)。它引起双链 DNA 断裂和复制突变,导致细胞凋亡,有...
BML-277
T2033
BML-277 (C 3742) 是一种选择性的检测点激酶 2 抑制剂,IC50为 15 nM。
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