tetrahydrocorticosterone

Tetrahydrocorticosterone (THB) is a glucocorticoid (GC) that has anti-inflammatory functions. For instance, 5α THB inhibits inflammatory actions by binding to GC receptor. HPLC studies in rat brains have reported that tetrahydrocorticosterone (THB) isomers are differentially distributed in males and females.

5α-Tetrahydrocorticosterone (5α-HB) 是一种内源性类固醇, 作为糖皮质激素受体 (glucocorticoid receptor) (GR) 的激动剂，同时是 Corticosterone 的代谢产物。这种化合物在体内是有效的局部抗炎剂。5α-Tetrahydrocorticosterone 通过降低大鼠肝细胞中代谢物与糖皮质激素受体-皮质酮及其 5α-还原代谢物的结合，显示出Kd值为 268 nM。在炎症性皮肤疾病的研究中，5α-Tetrahydrocorticosterone 具有重要应用。