ps-2

NPS-2143 (SB 262470A) 是口服活性溶钙剂， 是选择性钙敏感受体拮抗剂。它通过激活表达人 Ca2+受体的 HEK 293 细胞中的 Ca2+受体而引起的胞浆 Ca2+浓度增加，IC50值为43 nM。

NPS-2143 hydrochloride (NPS-2143 HCL) 是一种口服具有活性的溶钙剂，是钙敏感受体(CaSR)的选择性拮抗剂。它能够激活表达人 Ca2+受体的 HEK 293 细胞中的 Ca2+受体，从而增加胞浆 Ca2+浓度(IC50=43 nM)。

APS-2-79 hydrochloride (APS-2-79 HCl) 是一种 KSR 依赖性的MEK 拮抗剂，可与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2。它与 KSR 结合可将 KSR 处于非活性状态，使其无法再结合 RAF 和激活 MEK，从而阻断 Ras-MAPK 信号通路。

APS-2-79 是一种 KSR 依赖性的MEK 拮抗剂。APS-2-79 与 ATPbiotin 竞争性地结合到 KSR2-MEK1 复合物内的KSR2，IC50为 120 nM。APS-2-79 与 KSR 结合可将 KSR 固定在一个非活性的状态，使其无法再结合RAF 和激活MEK，从而阻断了 Ras-MAPK 信号通路。

MIPS-21335为PI3KC2α抑制剂（IC50：0.007 μM），亦能抑制PI3KC2β、p110α、p110β及p110δ（IC50分别为0.043、0.140、0.386、0.742 μM）。本化合物展现出抗血栓作用。

5'-O-TBDPS-2,2'-anhydrouridine is a Nucleoside Derivative - Protected nucleoside with NH2 OH open.

NPS2390 是钙敏感受体抑制剂，也是 mGluR1 和 mGluR5 的非竞争性拮抗剂。

ELN 318463 shows differential inhibition of presenilin (PS1)- and PS2-comprised γ-secretase with EC50s of 12 nM and 656 nM for PS1 and PS2, respectively. ELN 318463 is 51-fold more selective for PS1.ELN 318463 is an amyloid precursor protein (APP) selective γ-secretase inhibitor.

(R)-PS210, the R enantiomer of PS210 is a substrate-selective allosteric PDK1 activator with an (AC50 of 1.8 μM).

PS210 是针对 PDK1的 PIF 结合口袋的、选择性的、有效的 PDK1激活剂，对其他蛋白激酶无活性。在细胞中，它的前药 PS423 可作为 PDK1的底物选择性抑制剂，抑制 S6K 的磷酸化和活化。

I-BET469 is a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose.

CPS2，一种高效、选择性且不可逆的PROTACCDK2降解剂（IC50= 24 nM），用于急性髓系白血病的研究。

Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。

1,2-Dihexanoyl-sn-glycero-3-PS sodium 是一种磷脂，其在 sn-1 和 sn-2 位连接 Hexanoic acid。

(±)11(12)-EET is a fully racemic version of the R S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in the renal cortical collecting duct when used at a concentration of 100 nM.[5]11(12)-EET (50 μg kg per day) increases adhesion of isolated peripheral blood leukocytes in a chamber coated with P-selectin and ICAM-1 but does not affect choroidal neovascularization size following laser photocoagulation[6] It also has anti-inflammatory, angiogenic, and cardioprotective properties[7]

PROTAC BRD4 Degrader-8 is a potent BRD4 inhibitor, with IC50s of 1.1 nM and 1.4 nM for BRD4 BD1 and BD2, respectively. PROTAC BRD4 Degrader-8 is capable of potently degrading the BRD4 protein in PC3 prostate cancer cells[1]. PROTAC BRD4 Degrader-8 (compound 8; 6 days) inhibits the proliferation of PC3 prostate cancer cells, with an IC50 of 28 nM[1].PROTAC BRD4 Degrader-8 (4 h) suppresses MYC gene transcript in MV4-11 AML cells, with an IC50 of 11 nM[1].PROTAC BRD4 Degrader-8 (4 h) potently degrades the BRD4 protein in PC3 prostate cancer cells, with an DC50 of 7.5 nM[1]. [1]. Dragovich PS, et, al. Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy. J Med Chem. 2021 Mar 11;64(5):2576-2607.

N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine, also known as 5'-O-DMT-N4-Bz-dC, is a chemical compound utilized in the synthesis of oligodeoxynucleotides that incorporate a 3'-S-phosphorothiolate (3'-PS) linkage. It is valuable in investigating enzyme-catalyzed cleavage mechanisms within DNA.

Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) 是一种改性 PS 产品，经由 NADPH 氧化酶激活及 Lyso-PS 信号转导后得到。Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 能够利用巨噬细胞 G2A 功能，增强现有的受体 配体系统，进而解决中性粒细胞炎症。

聚苯乙烯微塑料(PS-MPs)是一种潜在的有毒危害物质，对斑马鱼心脏造成损害，同时能诱导小鼠雄性生殖毒性。

N-myristoyl-RKRTLRRL 抑制 PKC 底物结合，亦阻碍 Ca2+ 和磷脂酰丝氨酸（PS）依赖性组蛋白磷酸化，其中 IC50 为 5 μM；同样，N-myristoyl-RKRTLRRL 对组蛋白磷酸化的抑制作用中，IC50 为 80 μM。

16:0 Lyso PS (1-Palmitoyl-2-hydroxy-sn-glycero-3-phospho-L-serine (sodium)) 一种在生化反应中使用的试剂。