Levomecol, a broad-spectrum antibiotic derived from Streptomyces venezuelae, comprises Chloramphenicol and Methyluracil. It exerts its bacteriostatic effect by binding to the bacterial ribosome, inhibiting protein synthesis by blocking peptidyltransferase.
Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyltransferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae.