pacap (6 38), human, ovine, rat tfa

PACAP (6-38), human, ovine, rat TFA is a potent PACAP receptor antagonist with IC50 values of 30 nM, 600 nM, and 40 nM for the PACAP type I receptor, PACAP type II receptor VIP1, and PACAP type II receptor VIP2, respectively.

PACAP (1-38), human, ovine, rat TFA 是一种内源性神经肽，是 PAC1 受体的高亲和力激动剂。该多肽由 38 个氨基酸组成，通过与 PAC1 受体结合激活腺苷酸环化酶，诱导细胞内 cAMP 水平升高并触发下游信号传导。研究表明，PACAP (1-38), human, ovine, rat TFA 的 C 端酰胺化对其在 PAC1 受体上的生物活性并非必需，非酰胺化形式仍能表现出完整的激动效力。它在神经保护、调节胰岛素分泌以及血管舒张中发挥重要作用。

PACAP (1-27), human, ovine, rat TFA (PACAP 1-27 TFA), an N-terminal fragment of PACAP-38, is an effective PACAP receptor antagonist with IC50 values of 3 nM for rat PAC1, 2 nM for rat VPAC1, and 5 nM for human VPAC2.