oxaloacetate

iGOT1-01 是一种天冬氨酸转氨酶 1 (谷氨酸草酰乙酸转氨酶 1；GOT1) 抑制剂，在 GOT1/GLOX/HRP 测定中IC50为 11.3 μM，在 MDH 偶联 GOT1 酶法测定中IC50为 85 μM。它显示出抗癌活性。

Magnesium Oxaloacetate is an inhibitor of the amebicidal activity of activated murine macrophages, helping the parasite to survive within the mouse large intestine and increasing the survival of C. elegans exposed to H2O2.

Oxaloacetate-ion-CoA（Oxaloacetate ion-coenzyme A）为辅酶 A 的一种衍生物。

Malonyl-CoA-oxaloacetate-glyoxylate (Malonyl-coenzyme A-oxaloacetate-glyoxylate) 是辅酶 A 的衍生物。

Oxaloacetate decarboxylase 催化草酰乙酸的不可逆脱羧，生成丙酮酸和COIC2。它属于钠离子转运脱羧酶 (NaT-DC) 酶家族。Oxaloacetate decarboxylase 将脱羧反应的化学能转化为跨膜Na+离子电化学梯度。

Malate dehydrogenase (oxaloacetate-decarboxylating, NADP+) 是一种用于生命科学研究的生化试剂，能够作为生物材料或有机化合物应用于实验。

GOT1 inhibitor-1 (GOT1 inhibitor 2c) 是一种新型的、非共价的谷氨酸草酰乙酸转氨酶 1 (GOT1) 抑制剂(IC50:8.2 uM)，是一种戊酸衍生物。 它可用于以及胰腺导管腺癌 (PDAC) 。

(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。

Oxaloacetic acid 是一种代谢中间体，涉及多种途径，如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。

(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂，能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药，是一种广受欢迎的减肥食品补充剂。

Pyruvate Carboxylase-IN-5 (compound 6m) 是一种具备高度选择性和渗透性的丙酮酸羧化酶 (pyruvate carboxylase) 抑制剂。丙酮酸羧化酶是一种线粒体酶，催化丙酮酸转化为草酰乙酸，这个过程在维持三羧酸循环中间体的稳态水平中扮演关键角色，而这些中间体是氨基酸、脂肪酸和葡萄糖等生物大分子合成的前体。

Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected and hybrids were synthesized via substitution at piperazinyl-N4. The reaction of piperazinyl-NH of ciprofloxacin with selected drugs resulted in pronounced growth inhibition of standard as well as resistant bacterial strains[2]. The parent piperazine 6 was found to exhibit a reasonable activity toward the HeLa and MDA MB 231 tumor cell lines (IC50= 9.2 and 8.4 μΜ, respectively)[3]. Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[4].

Aspulvinone H is a natural inhibitor of glutamic oxaloacetate transaminase 1 (GOT1), suppressing glutamine metabolism, making PDAC cells sensitive to oxidative stress and inhibiting cell proliferation, exhibiting potent in vivo antitumor activity in an SW1990-cell-induced xenograft model.

Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxaloacetate transaminase (GOT) levels and increases glutamate pyruvate transaminase (GPT) and lactate dehydrogenase (LDH) levels, markers of xenobiotic stress, in the plasma of carp (C. carpio) when administered in tank water at a concentration of 10 µg/L. Clofibric acid has been found in wastewater effluent.

Malate dehydrogenase 催化草酰乙酸盐和苹果酸盐的相互转化，与二核苷酸辅酶的氧化/还原相关。

Aspartate aminotransferase (AST) 是一种转氨酶，常用于生化研究。Aspartate aminotransferase 催化天冬氨酸和 α-酮戊二酸转化为草酰乙酸和谷氨酸。Aspartate aminotransferase 可存在于在脑脊液、渗出液和渗出物。

Phosphoenolpyruvate carboxylase (PEPC) 是将磷酸烯醇丙酮酸同碳酸氢盐在 Mg2+ 存在下以不可逆的过程转变成草酰乙酸和无机磷的二氧化碳固定酶。该酶在催化景天酸代谢植物中二氧化碳(CO(2))的初级同化过程中发挥关键作用，并在植物代谢的昼夜模式设定中扮演主要角色。

Pyruvate carboxylase是一种催化反应中丙酮酸与HCO3−和MgATP进行依赖性羧化生成草酰乙酸的含生物素酶。它在调控肝脏糖异生、脂肪细胞脂肪酸合成及胰腺β细胞胰岛素分泌方面，对全身能量平衡发挥关键作用。

(S)-Malic acid (Standard) 是 (S)-Malic acid 的标准品，适用于定量分析、质量控制及生化实验等相关研究。(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸，是水果酸甜味的来源，常用作食品添加剂。

(-)-Hydroxycitric acid lactone (Standard) 是 (-)-Hydroxycitric acid lactone 的标准品。适用于定量分析、质量控制及生化实验等相关研究。(-)-Hydroxycitric acid lactone (Garcinia lactone) 是一种有效的 ATP-柠檬酸裂解酶抑制剂，能够催化柠檬酸盐线粒体外裂解为草酰乙酸和乙酰辅酶 A，限制了脂肪酸合成所需乙酰辅酶 A 单位的可用性。它是一种减肥药，是一种广受欢迎的减肥食品补充剂。

Oxaloacetic acid (Standard) 是一种可用于分析的标准物质，通常用作 Oxaloacetic acid 的研究和分析中参考的标准样品。Oxaloacetic acid 是一种代谢中间体，涉及多种途径，如葡萄糖异生、柠檬酸循环、乙醛酸循环、尿素循环、氨基酸合成和脂肪酸合成。

(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.

Citrate synthase 在三羧酸循环中催化第一步反应：乙酰辅酶 A 与草酰乙酸缩合生成柠檬酸盐。柠檬酸合酶位于真核细胞的线粒体基质中。

Citrate lyase 是一种酶，负责将柠檬酸转化为草酰乙酸。