ml 204

ML204 是有效的TRPC4 TRPC5通道选择性抑制剂，相比于 TRPC6 ，对TRPC4 TRPC5通道的选择性高出 19 倍，不影响其他的 TRP 通道和电压门控的钠、钾或 Ca2+通道。

ML204 hydrochloride (ML204 HCl) 是一种具有选择性和高效性的 TRPC4/TRPC5 通道拮抗剂，可阻断通过 μ-阿片受体刺激或鸟苷 5'-3-O-（硫代）三磷酸 （GTPgammaS） 的细胞内透析激活的 TRPC4β 电流。

HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50value of 56.4 ng/ml.1It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3HT-2 toxin has been found in cereal grains and food products.4,5 1.Nielsen, C., Casteel, M., Didier, A., et al.Trichothecene-induced cytotoxicity on human cell linesMycotoxin Res.25(2)77-84(2009) 2.Nathanail, A.V., Varga, E., Meng-Reiterer, J., et al.Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheatJ. Agric. Food Chem.63(35)7862-7872(2015) 3.Zhang, L., Li, L., Xu, J., et al.HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo developmentReprod. Toxicol.85104-109(2019) 4.Langseth, W., and Rundberget, T.The occurrence of HT-2 toxin and other trichothecenes in Norwegian cerealsMycopathologia147(3)157-165(1999) 5.Al-Taher, F., Cappozzo, J., Zweigenbaum, J., et al.Detection and quantitation of mycotoxins in infant cereals in the U.S. market by LC-MS/MS using a stable isotope dilution assayFood Control72(Part A)27-35(2017)

Tilapia piscidin 3 是具抗菌谱广的肽类化合物，有效对抗多种革兰氏阳性菌与阴性菌，其对 V. vulnificus 204、V. alginolyticus、S. agalactiae 819、E. faecalis BCRC 10066、S. agalactiae BCRC 10787 的最小抑菌浓度 (MIC) 分别为 2.44、2.44、9.78、19.55、0.61 μg mL。同時，Tilapia piscidin 3 对鱼红细胞显示出溶血性。