mitomycin a

Mitomycin A 是从链霉菌中提取出具有细胞毒性的抗生素，具有抗癌活性和抗肿瘤活性。Mitomycin A 可用于研究实体癌。

7-N-(4-Hydroxyphenyl)mitomycin C is a bioactive chemical.

Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 300 nM). Early in vitro studies showed that ansatrienin B potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. Ansatrienin B is a hydroquinone form of ansatrienin A .

Gentisuric Acid，作为Aspirin的代谢产物同时也是α-酰胺化单加氧酶（PAM）的底物，可抵御Mitomycin C导致的DNA损伤。

Porfiromycin is a n N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells.

Apaziquone (EOquin, EO9) 是一种吲哚喹诺酮类化合物，作为生物还原型前药，与较早的化疗化合物丝裂霉素C具有化学类似性。

Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fluorouracil , cisplatin , bleomycin , mitomycin C , and 6-mercaptopurine. It is an oxidized form of ansatrienin B .

RM 49 is a mitomycin C derivative that has antitumor activity in vitro.

KW 2149 is a compound derived from mitomycin C.

BMY-25551, 作为一种Mitomycin A 类似物，在细胞毒性方面，对小鼠和人类肿瘤细胞系展示出比Mitomycin C 高8至20倍的效果。此化合物广泛应用于癌症及血液学领域的研究。