matrix metalloproteinase-12 (mmp-12)

PF-00356231 hydrochloride 是基质金属蛋白酶 MMP-12 的抑制剂，IC50 为 1.4 μM。

ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。

MMP2-IN-2 是一种具有选择性的 MMP-2 (基质金属蛋白酶)抑制剂，具有潜在的抗癌抗肿瘤活性，抑制 MMP-13、MMP-9 和 MMP-8，可用于研究癌症和免疫疾病。

Aderamastat (FP-025) 是一种具有口服活性的基质金属蛋白酶12（MMP-12）抑制剂，适用于过敏性哮喘、COPD与肺纤维化的研究。

Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a critical enzyme involved in tissue remodeling and repair through its role in degrading extracellular matrix proteins, facilitating cell migration. This enzyme has been implicated in various physiological processes including vascular remodeling associated with aneurysm formation, wound healing, the progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII, a cell-permeable sulfonamide-based hydroxamic acid, effectively inhibits MMP-3 by binding to its active site (Ki = 23 nM), thus blocking its enzymatic activity. Additionally, this inhibitor has been demonstrated to suppress the activity of mouse macrophage metalloelastase MME MMP-12, with an IC50 value of 13 nM, highlighting its potential utility in research on tissue remodeling and disease processes involving MMPs.

Ageladine A dihydrochloride 是一种从海洋海绵Agelas nakamurai中提取的基质金属蛋白酶 (MMP) 抑制剂，并具有抗血管生成特性。它能抑制MMP-2、MMP-1、MMP-8、MMP-9、MMP-12和MMP-13，其IC50值为4.65 μM、2.79 μM、907.12 nM、1.83 μM、767.57 nM和1.09 μM。作为pH敏感的膜通透性染料，Ageladine A dihydrochloride在紫外线激发下呈现蓝绿色荧光，最大吸收峰为370 nm。此外，它作为一种稳定的荧光 pH 传感器，可用于监测细胞内pH值的变化。