e3 ligase ligand 10

E3 ligase Ligand 10 serves as a ligand for E3 ubiquitin ligase and can be conjugated to a protein ligand through a linker, resulting in the formation of PROTACs. These PROTACs act as inducers of ubiquitination-mediated degradation, specifically targeting cancer-promoting proteins[1].

Thalidomide-O-amido-PEG2-C2-NH2 TFA (E3 Ligase Ligand-Linker Conjugates 24 TFA) 包含基于 Thalidomide 的 cereblon 配体和 2 个单元的 PEG linker，是一种合成的 E3 连接酶配体-linker 偶联物。

(S,R,S)-AHPC-C10-NH2 (VH032-C10-NH2) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物 (E3 ligase ligand-linker conjugate)。用于 BET 的靶向 PROTAC 的合成。

cIAP1 Ligand-Linker Conjugates 10 comprise of an IAP ligand and a PROTAC linker, which facilitates the design of SNIPERs. These conjugates incorporate an IAP ligand that interacts with the E3 ubiquitin ligase, and a PROTAC linker. SNIPERs can be developed using cIAP1 Ligand-Linker Conjugates 10.

Pomalidomide-PEG1-C2-N3 is a compound that has been synthesized as a conjugate of an E3 ligase ligand-linker. This compound incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, which are commonly used in PROTAC technology. Utilizing Pomalidomide-PEG1-C2-N3, it is possible to design a selective CDK6 PROTAC degrader known as CP-10. CP-10 effectively induces the degradation of CDK6, displaying a DC50 value of 2.1 nM[1].

(S,R,S)-AHPC-PEG2-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-PEG6-C4-Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

(S,R,S)-AHPC-C10-NH2 dihydrochloride (VH032-linker 10) 包含基于 (S,R,S)-AHPC 的VHL 配体和 1 个 linker，是一种合成的 E3 连接酶配体-linker 偶联物，用于合成 BET 的靶向 PROTAC。

(S,R,S)-AHPC-Me-C10-NH2 hydrochloride 是一种合成的 E3 连接酶配体-接头偶联物，包含 VHL 配体和接头。

E3 Ligase Ligand-Linker Conjugate 112 属于E3 泛素酶配体+连接子偶联物 (E3 Ligase Ligand-Linker Conjugates) 类别，主要应用于制备 SMARCA2 degrader-10。

E3 Ligase Ligand-linker Conjugate 134，作为E3 连接酶配体与接头的复合体（conjugate of E3 ligase Ligand and linker），是制造PROTAC活性分子STING-IN-10的核心中间体。

Acepromazine-1-Piperazinepropanamine (compound 10) 为一种 E3 连接酶配体-linker 偶联物 (E3 Ligase Ligand-Linker Conjugate)，结合了cereblon配体及其 linker。该化合物通过靶蛋白配体连接技术，能够生成 PROTAC分子，命名为 TrimTAC1。

PROTAC BTK Degrader-10 (Example 1P) 是一种靶向BTK的PROTAC降解剂，用于慢性淋巴细胞白血病 (CLL) 的研究。(Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

E3 Ligase Ligand 50 是E3连接酶Cereblon的配体，可用于合成PROTACBTK Degrader-10。

CRBN ligand-10 (compound 18) 是一种CRBN型E3泛素连接酶配体，适用于PROTAC的制备。

E3 ligase Ligand 26（part of Compd 10）是一种E3 ligase的配体，专用于合成SOS1PROTAC降解剂。