dothiepin

Dothiepin（Dosulepin; Dothep）是一种具备镇静 抗焦虑作用的抗抑郁药物。该化合物主要通过抑制去甲肾上腺素的再摄取，而非血清素，以增强去肾上腺素能神经传递。同时，Dothiepin作为组胺H1受体的拮抗剂，具备显著的镇痛活性，适用于治疗心因性面部疼痛、特发性纤维肌痛综合征或类风湿关节炎，并且不具有心脏毒性。

Dothiepin HCl is a Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects.

Dothiepin-d6 HCl (N,N-dimethyl-d6) (cis trans mixture) 是 Dothiepin HCl 的氘代化合物。Dothiepin HCl 的 CAS 号为 25627-36-5。