cytarabine triphosphate

Cytarabine triphosphate (Ara-CTP), a competitive inhibitor of DNA synthesis and an active metabolite of Cytarabine, exhibits predictive potential for leukemic blasts' chemosensitivity to Cytarabine through intracellular levels.

Cytarabine triphosphate (Ara-CTP) trisodium 是 Cytarabine 的活性代谢物，为 DNA 合成的竞争性抑制剂。细胞内 Cytarabine triphosphate trisodium 的水平可预测白血病母细胞对 Cytarabine 的化学敏感性。

Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。

Fazarabine, also known as Kymarabine, is an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug.