combretastatin a1 phosphate tetrasodium

Combretastatin A-1 phosphate (OXi-4503) tetrasodium, a prodrug of Combretastatin A-1, is a tubulin-binding microtubule polymerization inhibitor that targets the colchicine-binding site. By inducing tubulin depolymerization, Combretastatin A-1 phosphate tetrasodium inhibits the Wnt β-catenin pathway and leads to the deactivation of AKT. It possesses both anti-tumor and anti-vascular properties.