cdk1/cyc a

CDK1 Cyc B-IN-1 (Compound 5) is a potent inhibitor of the CDK1 Cyc B complex, demonstrating selectivity with an IC50 value of 97 nM. This compound induces apoptosis and G2 M cell cycle arrest, effectively halting cancer cell proliferation. Additionally, CDK1 Cyc B-IN-1 exhibits a wide-ranging cytotoxic effect on various cancer cell lines [1].

Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。

Voruciclib 是一种具有口服活性和选择性 CDK 抑制剂，Ki 为 0.626 nM-9.1 nM。它在多种弥漫性大 B 细胞淋巴瘤模型中抑制 MCL-1 的表达。它有效阻断 MCL-1 的转录调节子 CDK9。

Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).