bat 1

ZD7114, also known as ICI-D7114, is a selective adrenoceptor agonist of brown fat and thermogenesis. ICI D7114 stimulates thermogenesis at doses that have little effect on beta 1 or beta 2 adrenoceptors. Treatment with ICI D7114 activates BAT and thermogenesis even in species and situations where the intrinsic capacity is low. ICI D7114 has beneficial effects in animal models of obesity and disturbed glucose and lipid homeostasis.

SARS-CoV-IN-5 (compound 49) 作为一种高选择性的非肽类非共价3CLpro抑制剂,对SARS-CoV-1、SARS-CoV-2和蝙蝠冠状病毒WIV1的3CLpro具有强效抑制作用,IC50值分别为38 nM、21.1 nM和86 nM.此外,SARS-CoV-IN-5能有效抑制SARS-CoV-2 delta变体的复制,其EC50为0.272 μM,并在K18-hACE2转基因小鼠模型中显著降低肺部病毒拷贝数.该化合物对SARS-CoV-1、WIV1、MERS、HCoV-OC43、HCoV-229E和HKU9等多种冠状病毒具有良好的抗病毒活性,显示出其广谱的潜在疗效.