as19

AS19 is a potent, selective 5-HT7 receptor agonist (IC50: 0.83 nM; Ki: 0.6 nM). AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis: 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively).

LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).

AS1949490 是选择性SHIP-2抑制剂，其IC50=620 nM。它能够通过上调L6肌管GLUT1基因激活葡萄糖代谢。

AS1938909 is a SHIP2 inhibitor that works by increasing Akt phosphorylation, glucose consumption, and glucose uptake in L6 myotubes, specifically upregulating the GLUT1 gene.

AS1907417 is a GPR119 agonist.

AS1928370 is an antagonist of transient receptor potential vanilloid 1 (TRPV1).

LAS191859 is a CRTH2 DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2 DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh2 that translates into a long-lasti

AS1975063 is a GPR40 agonist.

AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS TNFα, IC(50)=0.45n M; PHA TNFα, IC(50)=0.40 nM). In addition, equivalent concentrations of AS1940477 that inhibited cytokine production also inhibited TNFα- and IL-1 β-induced production of IL-6, PGE(2), and MMP-3 in human synovial stromal cells. AS1940477 was also found to potently inhibit TNF production in whole blood (IC(50)=12 nM) and effectively inhibited TNFα production induced by systemically administered LPS in rats at less than 0.1mg kg (ED(50)=0.053 mg kg) with an anti-inflammatory effect lasting for 20h after oral administration. Overall, this stu......

LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.

LAS190792 (AZD8999) 是一种毒蕈碱 (muscarinic) 拮抗剂及β2-肾上腺素能受体 (β2-adrenoceptor) 激动剂，其pIC50值针对 M1, M2, M3, M4, M5, β1, β2, β3 分别为 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6。该化合物作为支气管扩张剂具有应用潜力。

HOI-07 is a specific Aurora B inhibitor.

AS-1940477 hydrobromide is a p38 mitogen-activated protein kinase (MAPK) inhibitor.