apx 2

APX2039 是一种口服有效的真菌 Gwt1 酶 (fungal Gwt1 enzyme) 抑制剂，是新型Gwt2096抑制剂APX1的前药。APX2039 对 C. neoformans 和 C. gattii 展现出极强的抗氪球菌活性。APX2039 具有有效的抗真菌活性，科阻断 GPI (糖基磷脂酰肌醇)锚定细胞壁甘露蛋白的定位。APX2039 可用于研究隐球菌脑膜炎 (CM) 。

Oxycodegol phosphate is a mu​-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain

Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C.

APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage.

APX2009 is a second-generation APE1 Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.