94
49
2
1
34
Cat. No. | Product Name | ||
---|---|---|---|
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L1600 | 激酶抑制剂库 | 2720 compounds | |
2720 种激酶抑制剂/调节剂的独特集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
CL0146 |
JNK inhibitor kit
JNK inhibitor kit |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7677 |
JNK Inhibitor VIII
TCS JNK 6o |
JNK | MAPK |
JNK Inhibitor VIII (TCS JNK 6o) 是一种 c-Jun N-末端激酶(JNK-1, -2, -3)抑制剂,对 JNK-1、JNK-2 的IC50值分别是 45 nM 和 160 nM,对JNK-1、JNK-2、JNK-3 的Ki 分别为 2 nM、4 nM、52 nM。 | |||
T3598 |
JNK-IN-7
JNK inhibitor |
JNK | MAPK |
JNK-IN-7 (JNK inhibitor) 是 JNK 抑制剂,抑制 JNK1、JNK2和 JNK3,IC50分别为 1.5、2 和 0.7 nM。 | |||
T2668 |
JNK-IN-8
JNK Inhibitor XVI |
JNK; c-Kit | MAPK; Tyrosine Kinase/Adaptors |
JNK-IN-8 (JNK Inhibitor XVI) 是一种有效的JNK 抑制剂,抑制JNK1、JNK2和JNK3,IC50分别为 4.7、18.7 和 1 nM。 | |||
T2234 |
TCS JNK 5a
N-(3-氰基-4,5,6,7-四氢苯并[b]噻吩-2-基)-1-萘甲酰胺,SC202671,SC 202671,N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide,JNK Inhibitor IX,SC-202671 |
Apoptosis; JNK | Apoptosis; MAPK |
TCS JNK 5a (SC202671) 是一种 JNK2和 JNK3的有效抑制剂,pIC50分别为 6.5和 6.7。 | |||
T60534 |
JNK-IN-11
|
||
JNK-IN-11 (compound 1) 是一种有效的 JNK 抑制剂,具有用于阿尔茨海默病和帕金森病研究的潜力。JNK-IN-11对 JNK1、JNK2、JNK3 的IC50值分别为 1.8、21.4、2.2 μM 。 | |||
T38260 |
SP 600125, negative control
JNK Inhibitor II, negative control |
||
SP 600125, negative control 是 SP 600125 的甲基化类似物,可用作SP 600125的阴性对照,对 DTP3和GADD45β/MKK7(生长停滞和 DNA 损伤诱导型 β/介原活化蛋白激酶激酶 7)具有抑制作用,能够恢复活化。SP 600125, negative control 对 JNK2 和 JNK3 的 IC50s 分别为 18 和 24 μM。 | |||
T3109 |
SP600125
1PMV,JNK Inhibitor II,Nsc75890,Pyrazolanthrone |
Apoptosis; Ferroptosis; Trk receptor; JNK; Aurora Kinase; Autophagy | Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; MAPK; Tyrosine Kinase/Adaptors |
SP600125 (JNK Inhibitor II) 是一种 JNK 抑制剂,抑制 JNK1、JNK2 和 JNK3 (IC50=40/40/90 nM),具有口服有效性、可逆性和 ATP 竞争性。SP600125 是一种有效的铁死亡抑制剂,可以抑制自噬,诱导凋亡。 | |||
T79754 |
JNK-IN-14
|
JNK | MAPK |
JNK-IN-14是一种激酶(JNK1/2/3)抑制剂,IC50值为1.81、12.7和10.5 nM。它能诱导早期apoptosis,并在G2/M阶段引起细胞周期阻滞。与SP600125相比,在K562白血病细胞中,JNK-IN-14更强有效地抑制了Beclin-1的表达。 | |||
T79296 |
JNK-IN-12
|
JNK | MAPK |
JNK-IN-12(compound P2)是一种针对线粒体的JNK抑制剂,其IC50为66.3 nM,由线粒体特异性细胞穿透肽与特异性JNK抑制剂SP600125构成。该化合物特异性作用于线粒体JNK不影响核内JNK信号,能够抑制线粒体JNK磷酸化。JNK-IN-12在体内外模型中对帕金森病的改善显示出潜在效果。 | |||
T79489 |
JNK-1-IN-2
|
JNK | MAPK |
JNK-1-IN-2(Compound c6)是一种选择性JNK-1抑制剂,其IC50值为33.5 nM。同时,该化合物对JNK-2和JNK-3也具有抑制作用,其IC50值分别为112.9 nM和33.2 nM。通过抑制c-Jun蛋白的磷酸化,JNK-1-IN-2能够逆转肺部损伤,并且可以被应用于肺纤维化的相关研究。 | |||
T73109 |
JNK-1-IN-1
|
||
JNK-1-IN-1是JNK-1和MKK7的抑制剂,IC50值分别为7.8μM与MKK7。它通过与MKK7cp结合来抑制JNK-1的活性。 | |||
T61440 |
TOPK-p38/JNK-IN-1
|
||
TOPK-p38/JNK-IN-1 (Compound B12) is an orally active inhibitor of the TOPK-p38/JNK signaling pathway, with an IC50 value of 2.14 μM for the inhibition of NO production. It demonstrates anti-inflammatory properties by inhibiting downstream phosphorylation of related proteins and preventing the degradation of TOPK [1]. | |||
T40248 |
JNK3 inhibitor-1
JNK3 inhibitor-1 |
||
JNK3 inhibitor-1 is a highly potent and selective compound that specifically inhibits JNK3 with an impressive IC50 value of 0.005 μM. In addition to its remarkable inhibitory effects, JNK3 inhibitor-1 possesses excellent oral bioavailability and the ability to efficiently penetrate the brain. | |||
T62078 | Akt/NF-κB/JNK-IN-1 | ||
Akt/NF-κB/JNK-IN-1 (Compound 2i) 是一种 Akt、NF-κB 和 JNK 信号通路抑制剂。Akt/NF-κB/JNK-IN-1 对一氧化氮的产生表现出抑制作用 (IC50: 3.15 μM),表现出抗炎效果。 | |||
T6784 |
BI-78D3
|
JNK | MAPK |
BI-78D3 是底物竞争性的 JNK 抑制剂(IC50:280 nM),对 JNK 激酶活性具有抑制作用。 | |||
T16927 |
SR-3306
|
JNK | MAPK |
SR-3306 是一种能够透过血脑屏障的JNK 选择性抑制剂。 | |||
T3200 |
DB07268
|
JNK | MAPK |
DB07268 是选择性JNK1抑制剂,IC50值为 9 nM。 | |||
T12189 |
NBDHEX
|
Apoptosis; Glutathione Peroxidase; Autophagy | Apoptosis; Autophagy; Metabolism |
NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂,也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡,通过抑制 GST 的催化活性,避免抑制剂被特异性泵从细胞中排出,以及破坏 GSTP1-1和关键信号传导因子之间的相互作用,从而起到抗癌的作用。 | |||
T2675 |
Bentamapimod
AS 602801 |
JNK | MAPK |
Bentamapimod (AS 602801) 是一种ATP 竞争性的JNK 抑制剂,对JNK1、JNK2和JNK3的IC50分别为 80、90 和 230 nM。 | |||
T2035 |
WHI-P258
|
EGFR; JAK; JNK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; MAPK; Stem Cells; Tyrosine Kinase/Adaptors |
WHI-P258 是喹唑啉化合物,结合到JAK3的活性位点(Ki:72 µM)。甚至当WHI-P258到达 100 μM 时也不会抑制 JAK3 ,且对凝血酶诱导的血小板聚集无影响。 | |||
T14895 |
Tanzisertib
CC-930 |
JNK | MAPK |
Tanzisertib (CC-930) 是有效的JNK1/2/3抑制剂,IC50分别为61、7 和 6 nM。 | |||
T2343 |
AS601245
|
JNK | MAPK |
AS601245 是 c-Jun NH2-末端激酶 (JNK) 的抑制剂,具有神经保护特性。 | |||
T8477 |
IQ-3
|
JNK | MAPK |
IQ3 是c-JNK 家族选择性抑制剂,对JNK3 的选择性更好。它对JNK1、JNK2 和 JNK3 的Kd 值分别为0.24 μM、0.29 μM 和 0.066 μM。 | |||
T9010 |
IMM-H007
|
Others; AMPK | Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling |
IMM-H007 是一种新型降脂剂,可增加 abca1 蛋白的表达。 | |||
T9688 |
CC-90001
|
JNK | MAPK |
CC-90001 是口服有效的 c-Jun N 末端激酶选择性抑制剂。在基于细胞的模型中,CC-90001显示出对JNK1的选择性是JNK2的 12.9 倍。CC-90001在特发性肺纤维化方面有研究价值。 | |||
T13018 |
SU3327
halicin |
JNK | MAPK |
SU3327 (halicin) 是具有底物竞争性的 JNK 选择性抑制剂,IC50为 0.7 μM。它还抑制 JNK 和 JIP 之间的蛋白相互作用,IC50值为 239 nM。 | |||
T13099 |
TC ASK 10
|
ASK; MAPK | Apoptosis; MAPK |
TC ASK 10 是选择性的,口服有效的细胞凋亡信号调节激酶 1 抑制剂,IC50为 14 nM。它对其他代表性激酶的抑制活性低于 50%,除 ASK2之外 (IC50为 0.51 μM)。 | |||
T5833 |
CC-401 Hydrochloride
CC401 HCl |
JNK | MAPK |
CC-401 Hydrochloride (CC401 HCl) 是 JNK 抑制剂(Ki= 25~50 nM)。 | |||
T3627 |
IQ-1S free acid
IQ-1,IQ-1S,IQ-1S (free acid) |
NF-κB; JNK | MAPK; NF-κB |
IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。 | |||
T0860 |
Mefloquine hydrochloride
Mefloquin hydrochloride,Mefloquine HCl,盐酸甲氟喹 |
Potassium Channel; SARS-CoV; Reactive Oxygen Species; Parasite; Autophagy | Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; NF-κB |
Mefloquine hydrochloride (Mefloquin hydrochloride) 是喹啉抗疟药,是抗 SARS-CoV-2进入抑制剂,可研究疟疾、系统性红斑狼疮和癌症。它也是 K+通道(KvQT1/minK) 拮抗剂,IC50约为 1 μM。 | |||
T9138 |
Indirubin-3′-oxime
Indirubin-3'-monoxime |
GSK-3; CDK; JNK | Cell Cycle/Checkpoint; MAPK; PI3K/Akt/mTOR signaling; Stem Cells |
Indirubin-3′-oxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂,是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-catenin 信号来促进身高增长,可能在阿尔茨海默病的神经元凋亡中发挥作用。 | |||
T5097 |
Ezatiostat
TER199(free base),TLK199 |
Apoptosis; Glutathione Peroxidase; GST | Apoptosis; Metabolism; oxidation-reduction |
Ezatiostat (TER199(free base)) 是一种谷胱甘肽的三肽类似物,也是一种选择性的口服活性的谷胱甘肽 S-转移酶 P1-1 (GSTP1) 抑制剂。它通过抑制GSTP1导致 JNK 激活,刺激淋巴细胞生成和骨髓祖细胞增殖,可研究骨髓增生异常综合症。 | |||
T6927 |
Pamapimod
R1503,帕吡莫德,Ro4402257 |
p38 MAPK; Autophagy | Autophagy; MAPK |
Pamapimod (R1503) 是一种新型的选择性 p38 丝裂原活化蛋白激酶抑制剂,对于p38α和p38β的IC50分别为 14 nM 和 480 nM,Ki 分别为 1.3 nM 和 120 nM,对 p38δ 或 p38γ 亚型没有活性,可研究类风湿关节炎和其他自身免疫性疾病。 | |||
T78829 |
JNK2-IN-1
|
JNK | MAPK |
JNK2-IN-1(Compound J27)是一款具有抗炎活性的JNK2抑制剂,其解离常数为79.2 μM。该化合物能通过阻断NF-κB/MAPK信号通路来降低肿瘤坏死因子α(TNF-α)和白细胞介素6(IL-6)的释放,从而减轻脂多糖(LPS)引起的急性肺损伤(ALI)及脓毒症症状。 | |||
T74818 | JNK3 inhibitor-8 | ||
JNK3inhibitor-8是一种高效、选择性且具口服活性的JNK3抑制剂,能穿透血脑屏障。其对JNK3、JNK2、JNK1的IC50值依次为21, 2203, >10000 nM。JNK3inhibitor-8展现出显著的神经保护性能,并具备研究阿尔茨海默病(AD)的可能性。 | |||
T72714 |
JNK3 inhibitor-3
|
JNK | MAPK |
JNK3inhibitor-3(compound 15g)是一种选择性的c-Jun N-terminal kinase3(JNK3)抑制剂,具有良好的血脑屏障穿透性和口服生物利用度。其对JNK1、JNK2和JNK3的IC50分别为147.8 nM、44.0 nM和4.1 nM。在小鼠痴呆模型中,JNK3inhibitor-3能显著改善记忆功能,因此有望作为阿尔茨海默病研究的工具化合物。 | |||
T72715 |
JNK3 inhibitor-4
|
||
JNK3inhibitor-4 是一种强效的JNK3抑制剂(IC50=1.0 nM),属于2-芳基-1-嘧啶基-1H-咪唑-5-基乙腈衍生物。该化合物对JNK3表现出高度专一性,对比JNK1(IC50=143.9 nM)和JNK2(IC50=298.2 nM)的选择性显著。此外,JNK3inhibitor-4还具备神经保护特性及良好的血脑屏障透过性预期。 | |||
T0860L |
Mefloquine
Ro215998,WR 142490,Ro-215998,氟甲喹羟哌啶,Lariam,Ro 215998 |
Others | Others |
Mefloquine (Ro 215998) 是一种喹啉抗疟药,是一种抗 SARS-CoV-2 进入抑制剂。 Mefloquine 也是一种 K+ 通道 (KvQT1/minK) 拮抗剂,IC50 为 ~1 μM。它可用于疟疾、系统性红斑狼疮和癌症研究。 | |||
T74817 | JNK3 inhibitor-7 | ||
JNK3inhibitor-7 是一种有效的口服活性JNK3抑制剂,能穿过血脑屏障,其对JNK3、JNK2、JNK1的IC50值分别为53、973、1039 nM。该化合物表现出显著的神经保护作用,并具备研究阿尔茨海默病(AD)潜力。 | |||
T60805 |
JNK3 inhibitor-2
|
||
JNK3 inhibitor-2 是一种有效的选择性JNK3抑制剂。JNK3 inhibitor-2 对 JNK1、JNK2、 JNK3的IC50值分别为 >100, >100, 0.25 μM。JNK3 inhibitor-2也抑制 DDR1 和 EGFR (T790M, L858R)。 | |||
T1606 |
Fasudil
HA-1077,AT877,法舒地尔 |
ROCK; Serine/threonin kinase; Calcium Channel; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil (HA-1077) 是一种非特异性 RhoA/ROCK 抑制剂,也是 Ca2+通道拮抗剂和血管扩张剂。它对蛋白激酶有抑制作用,ROCK1 的 Ki 值为 0.33 μM,ROCK2 和 PKA、PKC、PKG 的 IC50值分别 0.158 μM 和 4.58 μM、12.30 μM、1.650 μM。 | |||
T38665 |
OVA-E1 peptide TFA
OVA-E1 peptide TFA |
p38 MAPK; JNK | MAPK |
OVA-E1 peptide TFA 在突变型和野生型胸腺细胞中都能同样地激活 p38 和 JNK 级联。 | |||
T22776 |
Ezatiostat hydrochloride
TLK199 HCl,Ezatiostat盐酸盐,TER199 |
Glutathione Peroxidase | Metabolism |
Ezatiostat hydrochloride (TLK199 HCl) 是一种新型谷胱甘肽类似物,可刺激淋巴细胞生成和骨髓祖细胞增殖,可用于治疗血细胞减少症和研究骨髓增生异常综合症。它也是口服活性的选择性谷胱甘肽 S-转移酶 P1-1 抑制剂,通过抑制 GSTP1导致 JNK 激活。 | |||
T3060 |
Fasudil hydrochloride
Fasudil (HA-1077) HCl,盐酸法舒地尔,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 |
ROCK; Serine/threonin kinase; Calcium Channel; HIV Protease; PKA; PKC; Autophagy | Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
Fasudil hydrochloride (HA-1077) 是一种非特异性RhoA/ROCK 抑制剂,也抑制蛋白激酶,对 ROCK1、PKA、PKC 和 MLCK 的 Ki 值分别为 0.33 μM、1.0 μM、9.3 μM 和 55 μM。 | |||
T10937L |
D-JNKI-1 acetate
D-JNKI-1 acetate(1445179-97-4 Free base),AM-111 acetate |
JNK | MAPK |
D-JNKI-1 acetate (AM-111 acetate) 是一种高效的细胞渗透性 JNK 肽抑制剂。 | |||
TP1353 |
L-JNKI-1
|
||
L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK, it has been shown to effectively inhibit JNK activity in in vivo studies. | |||
T10937 |
D-JNKI-1
XG-102,AM-111 |
JNK | MAPK |
D-JNKI-1 (AM-111) is a highly effective and cell-permeable peptide inhibitor. | |||
T5094 |
IRAK inhibitor 1
|
IRAK; JNK | Immunology/Inflammation; MAPK; NF-κB |
IRAK inhibitor 1 是IRAK-4抑制剂(IC50:216 nM),微弱抑制 JNK-1 (IC50:3.801 μM)和 JNK-2(IC50>10 μM)。 | |||
TP1897L1 |
JIP-1 (153-163) acetate(438567-88-5 free base)
|
JNK | MAPK |
JIP-1 (153-163) acetate(438567-88-5 free base) 是c-Jun N-末端激酶 (JNK) 的肽抑制剂,基于 JNK-interacting protein-1 (JIP-1) 的残基 153-163。以微摩尔范围内的亲和力与 JNK 结合,并抑制 p38 和 ERK。 | |||
T24784 |
SF5
SF-5,2,2-二苯基烷氢酸盐,SF 5 |
Apoptosis | Apoptosis |
SF5 是一种通过 JNK-p53-caspase 凋亡级联的凋亡通路抑制剂。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0089 |
Juglanin
|
Apoptosis; JNK; Autophagy | Apoptosis; Autophagy; MAPK |
Juglanin 是来自金鸡脚的一种黄酮类天然产物,是一种 JNK 的激活剂,能诱导人乳腺癌细胞的凋亡和自噬,具有炎症和抗肿瘤活性。 | |||
T5S2283 |
Sesamolin
|
p38 MAPK; Caspase; JNK | Apoptosis; MAPK; Proteases/Proteasome |
Sesaminol 是从Justicia orbiculata 中分离得到的一种天然产物,抑制脂质过氧化,具有神经保护作用和抗氧化活性。它通过抑制JNK、p38 MAPKs 和caspase-3磷酸化,抑制MAPK 的级联反应。 | |||
T7190 |
Actein
|
Apoptosis; Akt; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Actein 是从升麻的根茎中分离的一种三萜糖苷,通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖,诱导自噬和凋亡。 | |||
TMA0507 |
Tomatidine
|
NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB |
Tomatidine 通过阻断 NF-κB 和 JNK 信号传导而发挥抗炎作用。它在哺乳动物细胞或秀丽隐杆线虫中激活自噬。 | |||
T3S1641 |
Esculentoside H
|
TNF; NF-κB; JNK | Apoptosis; MAPK; NF-κB |
Esculentoside H 是一种皂苷,分离自多年生植物 Phytolacca esculent 的根提取物中,具有抗肿瘤作用。它的机制与 TNF 释放能力有关。它能够阻断 JNK1/2和 NF-κB 信号介导的基质金属蛋白酶-9 (MMP-9) 表达,抑制结肠癌细胞迁移。 | |||
TN3967 |
Epieriocalyxin A
|
ERK; BCL; ROS; Caspase; DNA/RNA Synthesis; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; MAPK; Proteases/Proteasome |
Epieriocalyxin A 可以抑制 Caco-2 结肠癌细胞的生长。它可能是未来结肠癌治疗的潜在药物。 | |||
T6758 |
Anisomycin
茴香霉素,Flagecidin,NSC 76712,Wuningmeisu C |
Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK; Microbiology/Virology |
Anisomycin (NSC-76712) 是一种从各种链霉菌属中分离出来的抗生素。 它通过抑制肽基转移酶或 80S 核糖体系统来干扰蛋白质和 DNA 合成。 | |||
T3876 |
Loureirin B
龙血素B,龙血素 B |
PAI-1; ERK; Potassium Channel; JNK | MAPK; Membrane transporter/Ion channel; Metabolism |
Loureirin B 是从剑叶龙血树中分离到的一种黄酮,是 PAI-1抑制剂,IC50值为 26.10 μM。它抑制 KATP,以及 ERK 和 JNK 的磷酸化,具有抗糖尿病的功效。 | |||
T3895 |
Polyphyllin I
重楼皂苷I,重楼皂甙 |
Apoptosis; Akt; JNK; PDK; mTOR; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling |
Polyphyllin I 是从七叶一枝花中提取的生物活性成分,具有很强的抗肿瘤活性。它是 JNK 信号通路的激活剂,也是 PDK1/Akt/mTOR 信号传导的抑制剂。它诱导自噬,G2/M 期阻滞和细胞凋亡。 | |||
T5574 |
Guggulsterone
Guggulsterone E&Z,香胶甾酮 |
Apoptosis; FXR; Akt; Caspase; JNK; Autophagy | Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Guggulsterone (Guggulsterone E&Z) E&Z 是来自Commiphora wightii 树中树胶脂的植物甾醇。 它通过下调抗细胞凋亡基因产物 ,调节细胞周期蛋白,激活caspases,JNK,抑制Akt,抑制多种肿瘤细胞的生长并诱导细胞凋亡。它是法尼醇 X 受体拮抗剂,可降低 CDCA 诱导的 FXR 活化。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T6S1371 |
Isovitexin
Homovitexin,Saponaretin,Apigenin-6-C-Glucoside,异牡荆黄素 |
NF-κB; JNK; Glucosidase | MAPK; Metabolism; NF-κB |
Isovitexin (Apigenin-6-C-Glucoside) 是从亚洲水稻种得到的一种黄酮,具有抗氧化和抗炎活性。它的作用与JNK1/2的抑制剂类似,抑制NF-κB 的活化。 | |||
T4592 |
TOMATIDINE HYDROCHLORIDE
Tomatidine,Tomatidine HCl,盐酸番茄碱 |
Others; NF-κB; JNK; Autophagy | Autophagy; MAPK; NF-κB; Others |
Tomatidine hydrochloride (Tomatidine HCl) 是一种甾体生物碱,可防止肌肉萎缩并促进肌肉生长。它通过阻断 NF-κB 和JNK 信号发挥抗炎作用,可激活哺乳动物细胞或秀丽隐杆线虫中的自噬。 | |||
T2A2481 |
Taurochenodeoxycholic Acid
Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine,牛磺鹅去氧胆酸 |
Apoptosis; TNF; Caspase; Endogenous Metabolite | Apoptosis; Metabolism; Proteases/Proteasome |
Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) 是动物胆汁酸的主要生物活性物质之一,可诱导细胞凋亡,具有明显的抗炎和免疫调节作用。 | |||
T13265 |
Urolithin B
尿石素B,3-羟基-6H-苯并[C]苯并吡喃-6-酮 |
ERK; NF-κB; Akt; Endogenous Metabolite; JNK; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Metabolism; NF-κB; PI3K/Akt/mTOR signaling |
Urolithin B 是一种 ellagitannins 的肠道微生物代谢产物,具有抗炎和抗氧化作用。它也是骨骼肌质量的调节因子,通过减少 IκBα 的磷酸化和降解来抑制 NF-κB 活性,并抑制 JNK、ERK 和 Akt 的磷酸化,并增强 AMPK 的磷酸化。 | |||
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
T1205 |
Chloramphenicol
Chlornitromycin,Levomycetin,Chloromycetin,氯霉素 |
ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic | Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Chloramphenicol (Chloromycetin) 是一种广谱抗生素,有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基,对肽基转移酶有活性,抑制肽键的形成。 | |||
T2872 |
Ginsenoside Re
人参皂苷 Re,Ginsenoside B2,Panaxoside Re,Chikusetsusaponin Ivc,Sanchinoside Re,人参皂苷Re |
Beta Amyloid; NF-κB; Endogenous Metabolite; JNK | MAPK; Metabolism; Neuroscience; NF-κB |
Ginsenoside Re (Ginsenoside B2) 是一种人参提取物,可降低 β-淀粉样蛋白 (Aβ),还通过抑制 JNK 和 NF-κB 发挥抗炎作用。 | |||
T3755 |
Pinostilbene
|
Others | Others |
Pinostilbene 是一种 Pterostilbene 的主要代谢物,能够抑制结肠癌细胞。 | |||
TN1879 |
Lucideric acid A
Lucidenic acid A,赤芝酸A |
MMP; p38 MAPK; JNK | MAPK; Proteases/Proteasome |
Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物,可抑制 PMA 诱导的MMP-9活性,具有抵抗肝癌细胞侵袭的作用。 | |||
T10383 |
Asatone
|
NF-κB | NF-κB |
Asatone 是一种从细辛中分离到的活性成分,通过活化 NF-κB 及下调 p-MAPK (ERK,JNK 和 p38) 通路起作用,具有抗炎作用。 | |||
T3816 |
Velutin
|
NF-κB; HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism; NF-κB |
Velutin 是一种苷元,提取自槲寄生中,能够抑制黑色素生物合成。它利用 NF-κB 途径减少破骨细胞分化和下调 HIF-1α。 | |||
T3908 |
10-Gingerol
10-姜酚 |
Apoptosis | Apoptosis |
10-Gingerol 是一种姜根脂的主要刺激性成分,具有抗炎、抗氧化和抗增殖作用,能够抑制 MDA-MB-231 肿瘤细胞的增殖(IC50:12.1 μM)。 | |||
TN2244 |
Sulfuretin
硫黄菊素 |
NF-κB; Autophagy | Autophagy; NF-κB |
Sulfuretin 是竞争性单酚酶和二酚酶活性抑制剂,IC50=13.64 μM。它通过抑制NF-κB 通路来抑制炎症反应。 它可用于过敏性气道炎症的研究。它减少氧化应激、血小板聚集和诱变。 | |||
T3008 |
Lawsone methyl ether
2-Methoxy-1,4-naphthoquinone,2-Methoxy-p-naphthoquinone,2-Methoxynaphthoquinone,2-甲氧基-1,4-萘并醌 |
Apoptosis; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology |
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) 是从凤仙花和Swertia calycina 中分离出的,有抗真菌和抗菌活性。 | |||
T5814 |
Aurantiamide
TMC-58B,橙黄胡椒酰胺 |
p38 MAPK; NF-κB | MAPK; NF-κB |
Aurantiamide 是马齿苋的活性成分,具有多种生物活性(如抗氧化、抗血小板、抗炎、抗肿瘤活性等),具有口服活性。 | |||
T3864 |
Erianin
|
BCL; Antibacterial | Apoptosis; Microbiology/Virology |
Erianin 能抑制吲哚胺-2,3-双加氧酶诱导的肿瘤血管生成,可用作退烧药和止疼剂。 | |||
T3676 |
Sesamol
1,3-Benzodioxol-5-ol,3,4-Methylenedioxyphenol,芝麻酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Sesamol (1,3-Benzodioxol-5-ol) 是芝麻油的主要成分,具有抗氧化和抗肿瘤活性。它是一种自由基清除剂,在 DPPH 实验中,IC50为 5.95±0.56 μg/mL。 | |||
T3S0737 |
Flavokawain A
2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A |
Apoptosis; p38 MAPK | Apoptosis; MAPK |
Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮,是一种抗癌试剂,具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡,有潜力用于膀胱癌的相关研究。 | |||
TN1702 |
Glycycoumarin
甘草香豆素 |
P450; JNK; AMPK; Autophagy | Autophagy; Chromatin/Epigenetic; MAPK; Metabolism; PI3K/Akt/mTOR signaling |
Glycycoumarin 是甘草中的一种香豆素,能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。它通过激活自噬,抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径,来抑制肝细胞脂性凋亡。它是一种雌激素激动剂,对 CYP1A2 和 CYP2B6 有中度抑制作用。 | |||
T4S1962 |
beta-Asarone
β-细辛脑,(Z)-1,2,4-三甲氧基-5-丙烯基苯;顺式细辛脑,Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin |
NF-κB; JNK | MAPK; NF-κB |
beta-Asarone (Cis-Isoelemicin) 是一种石菖蒲中的主要成分,具有免疫抑制、促进安定、中枢神经系统抑制、降温等功能。它可透过血脑屏障,能够预防帕金森病。 | |||
TCS2170 |
2,5-Dihydroxyacetophenone
Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,2 ',5'-二羟基苯乙酮,Acetylhydroquinone,2,5-二羟基苯乙酮,DHAP |
ERK; NF-κB; Tyrosinase | MAPK; NF-κB; Proteases/Proteasome |
2,5-Dihydroxyacetophenone (Quinacetophenone) 是从熟地黄中分离出的一种天然产物,通过阻断 ERK1/2和 NF-κB 信号通路,抑制活化巨噬细胞中炎症介质的产生。 | |||
T4S1469 |
Cucurbitacin IIb
葫芦素IIB,雪胆素乙 |
Apoptosis; Others | Apoptosis; Others |
Cucurbitacin IIb 是一种雪胆中的活性成分。它阻碍 STAT3,JNK 和 Erk1/2 的磷酸化,提高 IκB 和 NF-κB (p65) 的磷酸化水平,抑制 NF-κB (p65) 的核转位,降低 IκBα 和 TNF-α 的 mRNA 水平。它能够诱导细胞凋亡,具有抗炎作用。 | |||
T3398 |
Icaritin
Anhydroicaritin,去水淫羊藿黄素,Cycloicaritin |
Apoptosis; JAK; STAT; Autophagy | Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
Icaritin (Anhydroicaritin) 是Epimedium Genusis 的异戊二烯类黄酮衍生物,有效抑制 K562 细胞和原代 CML 细胞的增殖。它可以调节MAPK/ERK/JNK 和JAK2/STAT3/AKT 信号传导,并具有增强成骨的作用。 | |||
T2940 |
6-Hydroxyflavone
6-羟基黄酮,6-HF |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
6-Hydroxyflavone (6-HF) 是天然存在的黄酮化合物,具有抗炎作用。它对牛血红蛋白糖基化具有抑制作用。它能激活 AKT、ERK 1/2、JNK 信号通路,有效促进成骨细胞分化。它能抑制 LPS 诱导的 NO 的产生。 | |||
TL0004 |
FERULIC ACID METHYL ESTER
阿魏酸甲酯,Methyl ferulate,Methyl 4'-hydroxy-3'-methoxycinnamate |
p38 MAPK; Autophagy | Autophagy; MAPK |
FERULIC ACID METHYL ESTER (Methyl ferulate) 是从大百部中分到的阿魏酸衍生物,具有抗氧化和抗炎作用。在原发性骨髓源性巨噬细胞中,它抑制 COX-2 的表达,降低 p-p38和 p-JNK 的水平。它能够透过细胞膜和血脑屏障,清除自由基,可研究神经退行性疾病。 | |||
T6S1597 |
Mulberroside A
桑皮苷 A,桑皮苷A |
TNF; Tyrosinase; Interleukin | Apoptosis; Immunology/Inflammation; Proteases/Proteasome |
Mulberroside A 是桑中的一种主要活性成分,可降低TNF-α、IL-1β和IL-6的表达,抑制 NALP3、caspase-1 和 NF-κB 的激活以及 ERK、JNK 和 p38 的磷酸化 。它抑制蘑菇酪氨酸酶,具有抗炎和抗细胞凋亡作用。 | |||
TMA1004 |
Lucidenic acid F
|
p38 MAPK; JNK | MAPK |
Lucidenic acid F as a modulator of JNK and p38, it shows potent inhibitory effects on EBV-EA induction. | |||
TN4435 |
Licopyranocoumarin
|
P450; ROS; JNK | Immunology/Inflammation; MAPK; Metabolism |
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. | |||
T72236 |
erythro-Austrobailignan-6
|
||
erythro-Austrobailignan-6 是一种口服活性的抗癌化合物,能够抑制 DNA 拓扑异构酶 I 及 II 的活性,同时诱导细胞凋亡并增加 p38 和 JNK 的磷酸化。 | |||
T19960 |
Hinesol
(-)-Hinesol |
||
Hinesol is a unique sesquiterpenoid isolated from Atractylodes lancea rhizome. Hinesol has been found to induce apoptosis through the JNK signaling pathway in HL-60 cells. | |||
TN2039 |
Panaxydol
|
cAMP; p38 MAPK; JNK | GPCR/G Protein; MAPK |
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through NADPH oxidase and mitochondria. | |||
T80005 |
n-Butyl α-D-fructofuranoside
|
JNK | MAPK |
n-Butyl α-D-fructofuranoside,分离自Ulmus davidiana var. japonica的根皮,通过激活JNK促进Nrf2活性,并表现出抗炎效应。 | |||
TN5387 |
Grasshopper ketone
|
ERK; p38 MAPK; NO Synthase; JNK | Immunology/Inflammation; MAPK |
Grasshopper ketone 是从褐藻马尾藻中分离的化合物,是 RAW 264.7 细胞中 LPS 诱导的 NO 产生的有效抑制剂,通过抑制 MAPK(ERK,JNK 和 p38)和 NF-κB p65磷酸化来诱导抗炎作用。 | |||
TN1072 |
Lappaol A
|
P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
TN4410 |
Lappaol C
|
P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
TN5011 |
Shizukaol B
|
ERK; IL Receptor; p38 MAPK; TNF; NOS; NF-κB; COX; HIV Protease; DNA/RNA Synthesis; Prostaglandin Receptor; JNK | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome |
Shizukaol B exerts anti-inflammatory effects in LPS-activated microglia partly by modulating JNK-AP-1 signaling pathway; it also shows significant anti-neuroinflammatory effects by inhibiting nitric-oxide (NO) production in lipopolysaccharide (LPS)-stimul | |||
TN4411 |
Lappaol F
|
CDK; P-gp; JNK | Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju | |||
T37452 |
Stephacidin B
|
||
Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide ,in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively).1It induces apoptosis in HepG2 and Huh7 hepatoc... |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-04554 |
JNK1 Protein, Human, Recombinant (GST)
PRKM8,JNK,JNK-46,JNK21B1/2,JN... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 8 (MAPK8), also known as JNK1, is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. The protein kinases JNK1 has been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. It is critically involved in ... | |||
TMPY-04550 |
JNK2 Protein, Human, Recombinant (His)
JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAP... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n... | |||
TMPK-01203 |
TNFRSF19 Protein, Human, Recombinant (hFc)
AW123854,TRADE,TAJ α,AL023044,TAJ-α,Taj,TAJ alpha,Toxicity a... |
Human | HEK293 Cells |
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.22 kDa and the accession number is Q9NS6... | |||
TMPK-01204 |
TNFRSF19 Protein, Human, Recombinant (His)
Taj,TAJ-α,Toxicity and JNK inducer,TAJ-alpha,TRADE,... |
Human | HEK293 Cells |
A novel susceptibility gene TNFRSF19, which encodes an orphan member of the TNF receptor superfamily known to be associated with nasopharyngeal carcinoma (NPC) and lung cancer risk. TNFRSF19, a susceptibility gene for nasopharyngeal carcinoma and other cancers, functions as a potent inhibitor of the TGFβ signaling pathway. TNFRSF19 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 16.55 kDa and the accession number is Q9NS6... | |||
TMPY-02907 |
FGF-19 Protein, Human, Recombinant
fibroblast growth factor 19,FGF19 |
Human | E. coli |
FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF19 interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by KL, KLB and heparan sulfate glycosaminoglyca... | |||
TMPY-02115 |
R-Spondin 3/RSPO3 Protein, Human, Recombinant (aa 1-146, His)
CRISTIN1,THSD2,R-spondin 3,PWTSR |
Human | HEK293 Cells |
R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes. The RSPO family of secreted Wnt modulators is involved in development and disease and holds therapeutic promise as stem cell growth factors. The four members have high structural homology. RSPO2 and RSPO3 are more potent than RSPO1, whereas RSPO4 is relatively inactive. All RSPO members require Wnt ligands and LRP6 for activity and amplify s... | |||
TMPY-04572 |
MKK4 Protein, Mouse, Recombinant (His & GST)
MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated... |
Mouse | Baculovirus Insect Cells |
Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ... | |||
TMPY-02028 |
RON/CD136 Protein, Human, Recombinant (His)
CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON |
Human | HEK293 Cells |
The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in... | |||
TMPH-01251 |
DUSP26 Protein, Human, Recombinant (His & SUMO)
MKP-8,NATA1,DSP-4,SKRP3,DUSP26,MKP8,LDP-4,LDP4,DUSP24,Dual s... |
Human | E. coli |
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). | |||
TMPH-02209 |
TRAF5 Protein, Human, Recombinant (His & SUMO)
|
Human | E. coli |
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. | |||
TMPY-03655 |
GADD45G Protein, Human, Recombinant
GADD45γ,growth arrest and DNA-damage-inducible, γ,DDIT2,grow... |
Human | E. coli |
GADD45G, also known as CR6, is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being fr... | |||
TMPJ-00344 |
IL-18RAP Protein, Human, Recombinant (hFc & His)
IL-1R accessory protein-like,Interleukin-18 receptor β,C,IL1... |
Human | HEK293 Cells |
IL-18RAP is a single-pass type I membrane protein and contains two Ig-like C2-type domains and one TIR domain, IL18RAP can be induced by IFN-alpha and IL12 in nature killer cells and T-cells. The coexpression of IL18R1 and IL18RAP is required for the activation of NF-kappa B and JNK in response to IL-18.Defects in IL18RAP are associated with Coeliac disease. | |||
TMPK-00723 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)
CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNFRSF11A,OPTB7,NFKB,TRANCER,... |
Mouse | HEK293 Cells |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the acce... | |||
TMPJ-01353 |
MBIPP Protein, Human, Recombinant (His)
MAPK Upstream Kinase-Binding Inhibitory Protein,MUK-Binding ... |
Human | E. coli |
MAP3K12-binding inhibitory protein 1 (MBIP) is a 39kD protein high expression in the heart and lung. It is a component of the ADA2A-containing complex (ATAC) complex, a complex with histone acetyltransferase activity on histones H3 and H4, and composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1. In the complex, it probably interacts directly with KAT2A, CSRP2BP and WDR5. It’s function to inhibit the MAP3K12 activity to induce the activation of the JNK/SAPK pathwa... | |||
TMPY-04399 |
TAOK3 Protein, Human, Recombinant (aa 1-411, His & GST)
DPK,MAP3K18,TAO kinase 3,JIK |
Human | Baculovirus Insect Cells |
Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-9, CTCL-associated antigen HD-CL-9, Dendritic cell-derived protein kinase, JNK / SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and MAP3K18, is cytoplasm and peripheral membrane protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. Protein kinases are ... | |||
TMPJ-00700 |
GADD45B Protein, Human, Recombinant (His)
MYD118,Myeloid Differentiation Primary Response Protein MyD1... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It m... | |||
TMPH-01015 |
BMP-3 Protein, Human, Recombinant (His)
BMP3A,Bone morphogenetic protein 3A,BMP3,Osteogenin,Bone mor... |
Human | E. coli |
Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. BMP-3 Protein, Human, R... | |||
TMPJ-00711 |
GADD45G Protein, Human, Recombinant (His)
Cytokine-Responsive Protein CR6,Growth Arrest and DNA Damage... |
Human | E. coli |
Growth Arrest and DNA Damage-Inducible Protein GADD45 Υ (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. GADD45G is also involved in the regulation of growth and apo... | |||
TMPK-00351 |
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)
NF-KB,ODFR,PDB2,Rank,OSTS,NFKB,OPTB7,TNFRSF11A,LOH18CR1,CD26... |
Human | HEK293 Cells |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.85 kDa ... | |||
TMPJ-00358 |
DR6 Protein, Mouse, Recombinant (hFc & His)
BM-018,CD358,DR6,Tnfrsf21,Tumor necrosis factor receptor sup... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragm... | |||
TMPJ-00376 |
IL-17RD Protein, Human, Recombinant (hFc)
IL17Rhom,IL17RD,IL-17RD,IL-17 RD,IL17RLM,SEF,interleukin 17 ... |
Human | HEK293 Cells |
Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation ... | |||
TMPH-02194 |
TAB2 Protein, Human, Recombinant (His & Myc)
|
Human | Baculovirus Insect Cells |
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to ... | |||
TMPY-02191 |
BLNK Protein, Human, Recombinant (His)
BLNK-S,bca,SLP-65,B-cell linker,LY57,SLP65,AGM4,BASH |
Human | HEK293 Cells |
B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65 and BLNK, is a cytoplasm and cell membrane protein which contains oneSH2 domain. BLNK is expressed in B-cell lineage and fibroblast cell lines. Highest levels of expression is in the spleen, with lower levels in the liver, kidney, pancreas, small inte... | |||
TMPJ-00397 |
IL-17RA Protein, Human, Recombinant (His & Avi), Biotinylated
CD217,IL17RA,interleukin 17 receptor A,IL17Rinterleukin-17 r... |
Human | HEK293 Cells |
CD217, also known as Interleukin-17 receptor A, is a T cell expressed pleotropic cytokine with 866 amino acids in length. CD217 functions as receptors for IL17A and IL17F, it binds to IL17A with higher affinity than to IL17F and binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC. It also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC. The activation of IL17RA would lead to induction of expression of inflammatory chemokines... | |||
TMPY-02444 |
ATF2 Protein, Human, Recombinant (His & GST)
CREB2,CRE-BP1,CREB-2,TREB7,activating transcription factor 2... |
Human | Baculovirus Insect Cells |
Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has ... | |||
TMPY-04425 |
PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)
PRAK,MAPKAP-K5,MK-5,mitogen-activated protein kinase-activat... |
Human | Baculovirus Insect Cells |
MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulator... | |||
TMPY-02595 |
DUSP14 Protein, Human, Recombinant (His & MBP)
MKP6,MKP-L,dual specificity phosphatase 14 |
Human | E. coli |
Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (... | |||
TMPY-04374 |
MST4 Protein, Human, Recombinant (GST)
serine/threonine protein kinase 26,MST4,MASK |
Human | Baculovirus Insect Cells |
MST4, also known as mammalian STE2-like protein kinase 4, is a novel member of the germinal center kinase subfamily of human Ste2-like kinases and is closely related to MST3. The 416 amino acid full-length MST4 contains a C-terminal regulatory domain and an N-terminal kinase domain, both of which are required for full activation of the kinase. MST4 is highly expressed in the placenta, thymus, and peripheral blood leukocytes. MST4 specifically activates ERK but not JNK or p38 MAPK in transiently ... | |||
TMPJ-00674 |
RANK/TNFRSF11A Protein, Mouse, Recombinant (His)
Receptor activator of NF-KB,TNFRSF11A,Osteoclast differentia... |
Mouse | HEK293 Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acids (aa) signal peptide, 184 aa extracellular region , a 20 aa transmembrane domain and a 391 aa cytoplasmic region. Human and murine RANK share 81% aa identity in their extracellular domains. RANK is ubiquitous highly expressed in trabecular bone, thymus, small intestine, lung, br... | |||
TMPY-04460 |
OXSR1 Protein, Human, Recombinant (GST)
OSR1,oxidative stress responsive 1 |
Human | Baculovirus Insect Cells |
Oxidative stress-responsive 1 protein (OXSR1), also known as Serine/threonine-protein kinase OSR1, is a member of the Ser/Thr protein kinase family of proteins. OXSR1 regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. OXSR1 is a 58 kDa protein of 527 amino acids that is widely expressed in mammalian tissues and cell lines. The amino acid (aa) sequence of the predicted OXSR1 protein is 39% identical to that of human SOK1. Of... | |||
TMPY-04378 |
MAPKAPK3 Protein, Human, Recombinant (GST)
mitogen-activated protein kinase-activated protein kinase 3,... |
Human | Baculovirus Insect Cells |
The MAPKAP kinases are a group of MAP kinase substrates that are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identified and serve as substrates for the ERK and p38 MAP kinases. Mitogen-activated protein (MAP) kinase-activated protein kinase 3, also known as MAPKAPK-3 and 3pK, is a member of the Ser/Thr protein kinase family. It is widely expressed in hu... | |||
TMPY-02150 |
GADD45A Protein, Human, Recombinant (His & GST)
GADD45,growth arrest and DNA-damage-inducible, alpha,growth ... |
Human | Baculovirus Insect Cells |
GADD45A is a member of the GADD45 Family, and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions, including MAPK signaling, cell cycle regulation, DNA repair and genomic stability, apoptosis, and immune responses. The GADD45 Family of genes is rapidly induced by different stressors, including differentiation-inducing cytokines, and there is a large body of evidence that their cognate proteins are key players in cellular ... | |||
TMPJ-00060 |
IL-25/IL17E Protein, Human, Recombinant (His)
白细胞介素,IL17E,白介素,IL-17E,IL-25,IL25,Interleukin-25,Interleukin... |
Human | HEK293 Cells |
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammator... | |||
TMPH-02876 |
RIPK1 Protein, Mouse, Recombinant (His)
|
Mouse | E. coli |
Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold functions regulating inflammatory signaling and cell survival. Has kinase-independent scaffold functions: upon binding of TNF to TNFR1, RIPK1 is recruited to the TNF-R1 signaling complex (TNF-RSC also known as complex I) where it acts as a scaffold protein promoting cell survival, i... |